Circ_0003489 facilitates multiple myeloma progression by targeting miR-433-3p/PBX3 axis.

Background: Multiple myeloma (MM) is a relatively common hematologic tumor, and the study of non-coding RNAs in MM is gradually increasing. Our study aimed to reveal the regulatory mechanism of circular RNA_0003489 (circ_0003489)/microRNA-433-3p (miR-433-3p)/Pre-B-cell leukemia homeobox 3 (PBX3) axis in MM.

Methods: Circ_0003489, miR-433-3p and PBX3 contents were measured by real-time quantitative PCR or western blot.

Association between C-reactive protein levels and development of post-stroke depression: A systematic review and meta-analysis.

Background And Aims: Different prospective cohort studies have focused on the C-reactive protein (, a pentameric protein) biomarker as a predictor of post-stroke depression. In this review and meta-analysis, we will attempt to synthesize the evidence for the association between C-reactive protein and the development of post-stroke depression.

Methods: We systematically searched five academic databases for relevant studies according to the PRISMA guidelines.

Association between CpG island DNA methylation in the promoter region of and positive and negative types of schizophrenia.

Objective: To explore the association between CpG island methylation in the promoter region of and positive (type I) and negative (type II) types of schizophrenia, and investigate serum interleukin (IL)-1β, IL-6, and myelin basic protein (MBP) in schizophrenia.

Methods: Levels of CpG island methylation in the promoter region of were detected in peripheral blood of patients with schizophrenia (experimental group) and healthy individuals (control group), and serum IL-1β, IL-6, and MBP were measured.

Results: The positive rate of CpG island methylation in the promoter region of was higher in the experimental group than in the control group; however, there were no significant differences between type I and II patients.

Application value of UPLC-MS/MS in detecting serum concentration of anti-schizophrenic drugs in patients with mental illnes.

Objective: This study was designed to demonstrate the accuracy of ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in detecting serum concentration of anti-schizophrenic drugs in patients with mental illness.

Methods: The study participants were 186 schizophrenia patients treated in our hospital. Serum concentrations of anti-schizophrenic drugs in Chinese patients with mental illness were evaluated according to the reference intervals of drug therapy recommended in the guidelines.

Alterations of the Fecal Microbiota in Chinese Patients With Multiple Sclerosis.

Mounting evidence indicates that alterations in the intestinal microbiota may be associated with neurological disorders such as multiple sclerosis (MS). MS is a putative autoimmune disease of the central nervous system. However, it has not been determined whether the intestinal microbiota and host immune status are altered in Chinese patients with stable MS.

Expression characteristics of peripheral blood genes reveal potential biomarkers and candidate therapeutic targets for Parkinson's disease.

In neurodegenerative disease, Parkinson's disease is the second most common one. Current demographic trends tell that by 2030, the risk of prevalence is close to 4% and the incidence is expected to double. Understanding the detailed process of Parkinson's disease can help us to figure out new biomarkers and candidate therapeutic targets for the diagnosis and progression of PD.

Open-label, randomized, multiple-center, parallel study comparing glycemic responses and safety profiles of Glucerna versus Fresubin in subjects of type 2 diabetes mellitus.

Since the increase of prevalence of type 2 diabetes mellitus (T-2DM), the replacing quickly absorbed carbohydrates with a fat source rich in monounsaturated fatty acid to provide improved glycemic control in these patients has become an important assistant therapy. In the present study, we compared glycemic response and safety of two nutritional products, Glucerna and Fresubin, in Chinese subjects with T-2DM. Overall, 203 T-2DM subjects were randomly assigned (1:1) to either Glucerna or Fresubin.

Preserved postischemic heart function in sucrose-fed type 2 diabetic OLETF rats.

Cardiovascular disease is one of the most important causes of morbidity and mortality in diabetes mellitus, but there has been controversy over functional impairment of diabetic hearts and their tolerance to ischemia. We studied ischemic heart function in type 2 diabetic rats with different degrees of hyperglycemia and its relationship with cardiac norepinephrine release. Otsuka Long-Evans Tokushima Fatty rats (OLETF) and age-matched Long-Evans Tokushima Otsuka normal rats (LETO) were used.