Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization.

Background: Previous studies have suggested a potential association between AITD and MG, but the evidence is limited and controversial, and the exact causal relationship remains uncertain.

Objective: Therefore, we employed a Mendelian randomization (MR) analysis to investigate the causal relationship between AITD and MG.

Methods: To explore the interplay between AITD and MG, We conducted MR studies utilizing GWAS-based summary statistics in the European ancestry.

[Effect of collagen sponge on the healing process of alveolar fossa after tooth extraction in rats].

Purpose: To investigate the effect of collagen sponge on early bone healing process of alveolar fossa after tooth extraction in rats.

Methods: A total of 16 healthy female SD rats were selected. Animal models with tooth extraction were established.

Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo.

Purpose: Puerarin (CHO) is a phytoestrogen that possesses various pharmacological effect, and several researches have revealed the relationship between puerarin and bone metabolism. This study was aimed to evaluate the potential influence of puerarin on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) as well as on new bone formation following rapid maxillary expansion (RME) model in rats.

Methods: Rat BMSCs were adopted, and the cell proliferation was detected by cell-counting kit-8 (CCK-8) assay in vitro experiments.

Electrospun nanofibers containing chitosan-stabilized bovine serum albumin nanoparticles for bone regeneration.

Bone tissue engineering is becoming a key approach in bone repair and regeneration. In the present study, we fabricated a nanofiber scaffold containing chitosan-stabilized bovine serum albumin (BSA) nanoparticles for the delivery of abaloparatide and aspirin (ASA). The chitosan-stabilized BSA nanoparticles acted as a release barrier for the encapsulated abaloparatide.

Analysis of Cosmetic Effect of Nanocomposite Resin on Anterior Teeth.

The problems of anterior teeth include dental plaque, dental caries, and fracture, which are usually treated with common composite resin clinically. Although good repair effect can be achieved, patients are prone to anterior tooth sensitivity after surgery. Therefore, the purpose of this study is to analyze the cosmetic effect of nanocomposite resin on anterior teeth.

JAK2/STAT3 is associated with the inflammatory process in periapical granuloma.

Objective: It has been shown that JAK2/STAT3 is involved in the occurrence of various inflammatory diseases. The purpose of this study was to associate the expression of Janus kinase 2 (JAK2) and its receptor signal transducer and activator of transcription 3 (STAT3) and suppressors of cytokine signaling 3 (SOCS3), to periapical granuloma.

Methods: Samples were collected from 40 patients who were divided into two groups, namely, healthy control (N=20) and periapical granuloma (N=20) groups in accordance with classified standards.

Correlation between gene polymorphism and oral squamous cell carcinoma.

Correlation between phosphatase and tensin homolog deleted on chromosome ten () gene polymorphism and oral squamous cell carcinoma (OSCC) was investigated. A total of 33 OSCC patients were studied and 33 healthy individuals were included as the control group. Correlation between gene and OSCC was explored via quantitative polymerase chain reaction (qPCR), immunohistochemistry and western blot analysis.

miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7.

The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex-determining region Y-box 7 (SOX7) gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells .

[Expression and clinical significance of PUMA gene in salivary adenoid cystic carcinoma].

Purpose: To explore the expression of p53 up-regulated modulator of apoptosis (PUMA) gene in salivary adenoid cystic carcinoma (SACC) and its clinical significance.

Methods: The expressions of PUMA gene and protein were detected in 27 SACC tumor-adjacent tissues (group A) and 27 SACC tumor tissues (group B) with real-time quantitative PCR and Western blot. Statistical analysis was performed using SPSS 19.

[The clinical value of combining multiple features of CT in discriminating between benign and malignant lung lesions].

Objective: To develop a set of combined criteria of multiple features of chest CT for discriminating between benign and malignant lung lesions.

Methods: Patients whose chest CT showed abnormalities were recruited from the West China Hospital in March and April 2010. The patients were examined with bronchoscopy and the results of CT and pathology were compared.

Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases.

Adrenal composite pheochromocytoma is rare, most of which is functional, and extra-adrenal composite paraganglioma is extremely rare. We describe and compare the clinicopathological and immunohistochemical features of a retroperitoneal extra-adrenal composite paraganglioma and an adrenal composite pheochromocytoma. Both tumors were nonfunctioning and laboratory tests revealed no biochemical abnormalities.

[Establishment of an experimental animal model with alveolar bone defect by surgery in rats].

Purpose: To establish an animal model for experimental study of orthodontic treatment of alveolar bone defect and other relative research.

Methods: The experiment was carried out on forty SPF female Wistar rats,which were 6 weeks old. With the rats anaesthetized, one side of the alveolar bone in the maxillary first molar of the rats was removed partly.

Distribution and patterns of lymph nodes metastases and micrometastases in the mesorectum of rectal cancer.

Background And Objectives: Facts buried in the mesorectum remain to be unveiled. This study investigated the number, size, and detailed distribution of lymph nodes metastases and micrometastases within the mesorectum of rectal cancer.

Methods: Thirty-one patients who underwent total mesorectal excision (TME) were treated with lymph node revealing solution to retrieve lymph nodes, which were submitted to hematoxylin and eosin (HE) examination and immunohistochemical (IHC) staining.

The microvascular thrombi of colonic tissue in ulcerative colitis.

Mucosal microvascular thrombi in rectal biopsies were observed in some ulcerative colitis (UC). Heparin may be effective in steroid resistant UC in some studies, however, the new results of meta-analysis demonstrated a non-significant effect of heparin in controlled clinical trials, differing markedly from observational studies. The objective of this study was to identify colonic microvascular thrombi in larger cases with UC, and analyse its possible risk factors: age, gender, histologic score, extent of lesions and operation or biopsy specimens, and assess the significance of microvascular thrombosis in patients with UC.

[Correlation study between sex and age of patients and root resorption after orthodontic treatment].

Purpose: To investigate the relationship between root resorption related to fixed appliance and the variables including sex, age.

Methods: 44 patients were divided into four groups according to sex and age: juvenile males, juvenile females, adult males, adult females. The length of incisors was calculated according to orthopantomograph and study models of pre- and post-treatment, and the relationship between patients' sex and age and root absorption pre- and post-treatment was analyzed by paired t test.

[Hemangioma and vascular malformation of small intestine: a clinicopathologic analysis of fifty-one cases].

Objective: To investigate the clinicopathologic features of small intestinal hemangioma and vascular malformation.

Methods: A retrospective analysis was performed on 51 cases of hemangioma and vascular malformation involving the duodenum, jejunum and ileum in the past 30 years.

Results: The patient's age ranged from 1.

[Study with large slice technique and tissue microarray on lymph node involvement and micro-metastasis of rectal cancer].

Objective: To study lymph node involvement and micro-metastasis of rectal cancer with large slice technique and tissue microarray.

Methods: Large slice technique, combined with tissue microarray,was used in pathologic study of 31 patients after total mesorectal excision (TME) for rectal cancer.

Results: Nine hundred and ninety- two lymph nodes were harvested and 148 were positive.

Mesorectal spread and micrometastasis of rectal cancer studied with large slice technique and tissue microarray.

Background And Objectives: Mesorectal tissue seems to be an ideal substrate for the spreading of tumors. The aim was to study the distribution of mesorectal neoplastic foci, examine occurrence of circumferential margin involvement and investigate micrometastasis of the lymph nodes.

Methods: A large slice technique, combined with tissue microarray, was used in the pathologic study of 31 specimens operated on following the principles of total mesorectal excision (TME).

Patterns of neoplastic foci and lymph node micrometastasis within the mesorectum.

Background And Aims: Local recurrence after rectal cancer surgery is conceived to result from microscopically incomplete resection. We aimed to investigate the patterns of mesorectal neoplastic foci, and examined the involvement and micrometastasis of lymph nodes.

Methods: Observation of large tissue slice and analysis of tissue microarray were integrated in the pathological study of 31 total mesorectal excision (TME) specimens.

Nodal spread and micrometastasis within mesorectum.

Aim: To study the distribution of positive lymph nodes within mesorectum and to investigate the possible micrometastasis in negative lymph nodes.

Methods: Large slice technique combined with tissue microarray was used in the pathologic study of 31 specimens.

Results: A total of 992 lymph nodes were harvested and cancer metastasis was found in 148 lymph nodes.

Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis.

Aim: Glucocorticoid (GC) resistant ulcerative colitis (UC) remains a serious disease and is difficult to manage. Although the molecular basis of GC insensitivity is still unknown, GC receptors (GRalpha and GRbeta) may play an important role in it. This study was aimed to investigate the relationship between the expression of GRalpha and GRbeta in colonic mucosal cells of patients with UC, the efficacy of GC therapy and the intensity of inflammation.

Microscopic spread of low rectal cancer in regions of the mesorectum: detailed pathological assessment with whole-mount sections.

Background And Aims: The aim was to investigate the regional spread of microscopic tumor nodules in the mesorectum of patients with low rectal cancer, and to provide further pathological evidence for optimal procedure selection of radical resection for rectal cancer.

Patients And Methods: Sixty-two patients with low rectal cancer underwent low anterior resection and total mesorectal excision (TME). Surgical specimens were sliced transversely on serial embedded blocks at 2.

[Interobserver reproducibility in the pathologic diagnosis of borderline ductal proliferative breast diseases].

Objective: The aim of this study involving general pathologists was to assess interobserver reproducibility in the pathologic diagnosis of borderline ductal proliferative breast diseases.

Methods: Ten general pathologists independently reviewed 43 specimens chosen to represent the spectrum of borderline ductal proliferative breast lesions. All slides were blindly reviewed without given standardized criteria, and were classified as either mild usual hyperplasia, moderate-severe usual hyperplasia, mild atypical hyperplasia, moderate-severe atypical hyperplasia, ductal carcinoma in situ, or ductal carcinoma in situ with invasion.