Publications by authors named "Daisy Villa"
Background: The mean age of dengue has been increasing in some but not all countries. We sought to determine the incidence of dengue virus (DENV) infection in adults and children in a prospective cohort study in the Philippines where dengue is hyperendemic.
Methodology/principal Findings: A prospective cohort of subjects ≥6 months old in Cebu City, Philippines, underwent active community-based surveillance for acute febrile illnesses by weekly contact.
Proper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952-2012).
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- - A study in Cebu City, Philippines from 2012-2013 explored the prevalence of symptomatic and subclinical Chikungunya virus (CHIKV) infections, finding that subclinical cases were much more common, occurring at a ratio of 4.6:1 compared to symptomatic cases.
- - Of the 853 participants, the study identified 19 symptomatic infections and 87 subclinical infections, with the rate of subclinical infections varying significantly by age.
- - High baseline CHIKV antibody levels were found to provide complete protection against symptomatic infections, and genetic analysis revealed a close relationship between local strains and those found in Asia and the Caribbean.