Buprenorphine and methadone differentially alter early brain development in human cortical organoids.

Buprenorphine (BUP) and methadone (MTD) are used for medication-assisted treatment (MAT) in opioid use disorder. Although both medications show improved maternal and neonatal outcomes compared with illicit opioid use during pregnancy, BUP has exhibited more favorable outcomes to newborns than MTD. The underlying cellular and molecular mechanisms for the difference between BUP and MTD are largely unknown.

A Test of the Kin Selection Hypothesis for Female Gynephilia in Thailand.

Female gynephilia (i.e., sexual attraction to adult females) is considered an evolutionary paradox because it reduces direct reproduction, yet it is influenced by genetic factors and has persisted over time and across different cultures.