Production of Bioactive Compounds from the Sulfated Polysaccharides Extracts of : Post-Extraction Enzymatic Hydrolysis Followed by Ion-Exchange Chromatographic Fractionation.

This paper describes a novel combined post-extraction process for obtaining bioactive compounds from the aqueous high molecular weight sulfated polysaccharides (SPs) extracts of the green algae, . After extracting the SPs, they were enzymatically hydrolyzed then the hydrolysate (V45) was fractionated into eight different molecular weight fractions (F1-F8) using ion exchange chromatography. Crude SPs together with V45 and (F1-F8) were examined for their carbohydrate, protein, and sulfate contents.

Crystal structure of 2-cyano-N'-(cyclo-hexyl-idene)acetohydrazide.

In the title compound, C9H13N3O, the cyclo-hexyl-idene ring adopts a chair conformation and the bond-angle sum at the C atom linked to the N atom is 359.6°. The cyano-acetohydrazide grouping is close to planar (r.

2-(4-Oxo-3-phenyl-1,3-thia-zolidin-2-yl-idene)malononitrile.

In the title compound, C12H7N3OS, the essentially planar thia-zole ring (r.m.s.

Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity.

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed.