Publications by authors named "Daisuke Watahiki"
Article Synopsis
- - A pediatric patient on high-dose methotrexate (MTX) therapy experienced delayed excretion due to a switch from oral to intravenous voriconazole, which contains sulfobutylether-β-cyclodextrin (SBECD) that may inhibit renal excretion of certain drugs.
- - An experiment with rats showed that SBECD pretreatment significantly delayed the renal clearance of phenolsulfonphthalein (PSP), particularly at higher doses, suggesting SBECD's role in affecting drug elimination.
- - The report advises against using IV drugs containing SBECD for patients receiving high-dose MTX treatment and calls for more research to confirm how SBECD impacts the renal excretion of MTX
This study was performed for a better understanding of the pharmacokinetics of sildenafil (SIL) and N-desmethyl sildenafil (DMS) in 13 children treated in the intensive care unit (ICU). Blood samples were taken periodically after the first oral administration of SIL (0.5 mg/kg).
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