Safety and feasibility of in-hospital autonomous transportation using a driverless mobility for patients with musculoskeletal disorders: preliminary clinical study to achieve mobility as a service in medical care.

Background: Recent advancements in and the proliferation of autonomous mobility technology, such as intelligent wheelchairs, have made it possible to provide mobility services for patients with reduced mobility due to musculoskeletal disorders. In the present study, we conducted a preliminary clinical study to assess the safety and feasibility of in-hospital autonomous transportation using a driverless mobility (wheelchair) for patients with musculoskeletal disorders.

Methods: From January to February 2022, 51 patients with musculoskeletal disorders exhibiting gait disturbance who presented to our institution were included in the present study.

Comparison of outcomes of different osteotomy sites for hallux valgus: A systematic review and meta-analysis.

Background: Hallux valgus (HV) is a common foot deformity for which several corrective surgical procedures, with different osteotomy sites, have been reported. The purpose of the present study was to systematically review randomized (RCTs) or controlled (CCTs) clinical trials and perform meta-analysis on outcomes of different osteotomy sites of the first metatarsal.

Methods: An extensive literature search was conducted in PubMed and the Cochrane Library from January 1983 to July 2020.

Treatment of Periprosthetic Humeral Shaft Fracture after Total Elbow Arthroplasty in an Osteoporotic Patient, using the Ilizarov External Ring Fixator: A Case Report.

Introduction: Periprosthetic humeral shaft fracture after total elbow arthroplasty (TEA) and open reduction and internal fixation at the same side humeral neck fracture in patients with osteoporosis poses a treatment challenge. Herein, we describe our experience with its treatment using the Ilizarov external ring fixator.

Case Report: A 74-year-old Japanese woman with rheumatoid arthritis and osteoporosis sustained a periprosthetic humeral shaft fracture.

Location of fractures and the characteristics of patients with atypical femoral fractures: analyses of 38 Japanese cases.

The purpose of this study was to determine fracture location and the characteristics of patients with atypical femoral fractures (AFFs). We studied 38 AFFs in 34 patients admitted to our institution between November 2007 and July 2013. The diagnostic criteria for the AFFs were based on 2014 American Society of Bone and Mineral Research guidelines.

Hypoxia responsive mesenchymal stem cells derived from human umbilical cord blood are effective for bone repair.

Mesenchymal stem cells (MSCs) are highly useful in a variety of cell therapies owing to their multipotential differentiation capability. MSCs derived from umbilical cord blood are generally isolated by their plastic adherence without using specific cell surface markers and examined for their osteogenic, adipogenic, and chondrogenic differentiation properties retrospectively. Here, we report 2 subpopulations of MSCs, separated based on aldehyde dehydrogenase (ALDH) activity.

GATA2-dependent and region-specific regulation of Gata2 transcription in the mouse midbrain.

Transcription factor GATA2 is expressed in numerous mammalian tissues, including neural, hematopoietic, cardiovascular and urogenital systems, and yet it plays important roles in the regulation of tissue-restricted gene expression. The Gata2 gene itself is also under stringent tissue-specific control and multiple cis-regulatory domains have been identified in the Gata2 locus. In this study we sought out and then examined in detail the domains that regulate Gata2 in the midbrain.