Publications by authors named "Daisuke Hayashi"
The objective of this study was to reveal the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for Japanese patients with treatment-resistant depression (TRD) in clinical practice, based on real-world data from a nationwide multicenter observational study in Japan. Clinical data of patients with TRD treated with rTMS (NeuroStar TMS treatment system) under public insurance coverage were retrospectively collected from 21 institutes nationwide between June 2019 and December 2023. Depression severity was assessed by the 17-item Hamilton Depression Rating Scale (HAMD-17).
View Article and Find Full Text PDFA vast number of mass flow controllers (MFCs) are used in semiconductor industry. For the stable supply, an efficient production method of MFC is required. The gain tuning of the proportional-integral (PI) control to realize a setting flow rate is essential for efficient mass production.
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- Histiocytic necrotizing lymphadenitis (HNL) is a painful inflammatory disease with an unclear cause, and this study focused on the role of interferon (IFN)-α in its development and diagnosis.
- The study involved 47 HNL patients and 43 others with similar conditions, using various techniques to measure IFN-stimulated genes and serum levels of IFN-α.
- Results showed higher levels of ISG and serum IFN-α in HNL patients compared to those with malignant lymphoma, suggesting that IFN-α could be a key factor in HNL and a useful marker for its diagnosis and monitoring.
Article Synopsis
- - The study analyzed the link between the number of guideline-directed medical therapy (GDMT) drugs and mortality in heart failure patients, involving 3,146 participants divided based on their prescribed medications at discharge.
- - Findings showed that patients with 5 or more GDMT drugs and fewer than 4 non-GDMT (ni-GDMT) drugs had the lowest mortality rates, while those with less GDMT and more ni-GDMT drugs had the highest mortality rates over a three-year period.
- - The results emphasized that the number of ni-GDMT drugs significantly impacted three-year mortality, suggesting that managing ni-GDMT is essential for improving outcomes in heart failure treatment, while the amount of GDMT alone did not worsen
Introduction: The clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression (TRD) in Japan has not been adequately investigated. Furthermore, the relationship between stimulation-site pain and the antidepressant effects of rTMS has not been thoroughly examined. Therefore, this study aimed to clarify (1) the real-world efficacy and safety of rTMS for TRD in Japan and (2) the relationship between stimulation-site pain and clinical improvement of depressive symptoms.
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- Pimobendan is known to help with the symptoms of heart failure, but there's little evidence showing it improves long-term outcomes.
- This study evaluated 175 heart failure patients, finding that those with reduced ejection fraction who received guideline-directed medical therapy (GDMT) alongside pimobendan had lower rehospitalization rates compared to those who didn't get GDMT.
- The results suggest that adding GDMT may be beneficial for specific heart failure patients, but more extensive research is required to confirm these findings.
Article Synopsis
- * The study investigated producing Mycobacterial DNA-binding protein 1 (MDP1) using two methods, recombinant proteins from E. coli and Mycolicibacterium smegmatis, to test their ability to boost the immune response in BCG-vaccinated individuals.
- * Results indicated that mMDP1, derived from the avirulent Mycolicibacterium smegmatis, was most effective in stimulating IFN-gamma production when combined with a novel CpG DNA called G9.1
Background: Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age.
Methods: Stool samples were collected from one-and-a-half-year-old food-allergic (FA group, n = 29) and healthy controls (HC group, n = 19).
Red blood cell (RBC) transfusion therapy is often performed in patients with acute heart failure (AHF) and anemia; however, its impact on subsequent cardiovascular events is unclear. We examined whether RBC transfusion influences major adverse cardiovascular events (MACE) after discharge in patients with AHF and anemia.We classified patients with AHF and anemia (nadir hemoglobin level < 10 g/dL) according to whether they received RBC transfusion during hospitalization.
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- This study investigates the role of fractional excretion of urea nitrogen (FEUN) in identifying worsening renal function (WRF) and its relationship with outcomes in patients with acute heart failure (AHF).
- Among 1,103 AHF patients, those with WRF had significantly higher rates of heart failure readmission, particularly when FEUN values were low or high.
- The findings suggest that monitoring FEUN can help predict which AHF patients may have poor outcomes related to renal function, emphasizing its clinical importance in managing these patients.
Background: Some patients with food protein-induced enterocolitis (FPIES)-like allergy do not completely fulfill the diagnostic criteria of the international consensus guideline for FPIES. However, it is unclear whether such FPIES-like patients represent a completely different population from FPIES.
Objective: This study aimed to clarify differences in characteristics between patients with FPIES who fully met diagnostic criteria and those who partly met them.
Article Synopsis
- * The research involved creating a new platform using the BCG Tokyo strain, where the mpb70 gene was found to be the most active and was used to express a polyhistidine tag that could be secreted, promising effective antigen delivery.
- * The study also demonstrated that an rBCG expressing the receptor binding domain (RBD) of SARS-CoV-2 could effectively secrete this protein even after freeze-drying, indicating potential for practical applications in vaccine development.
Article Synopsis
- GLP-1 receptor agonists, like semaglutide, show promise for weight management, with patients reporting decreased "food noise," which is the obsessive thinking about food.
- The narrative review focuses on research concepts that help understand food noise, especially how individuals react to food cues internally and externally.
- The authors introduce the Cue-Influencer-Reactivity-Outcome (CIRO) model, which outlines the factors influencing food cue reactivity and offers a framework for future research on food noise and eating behavior.
Quality of measurement properties of medication adherence instruments in cardiovascular diseases and type 2 diabetes mellitus: a systematic review and meta-analysis.
Syst Rev
November 2023
Article Synopsis
- The study focuses on evaluating and comparing patient-reported outcome measures (PROMs) to assess medication adherence in patients with cardiovascular diseases and type 2 diabetes, highlighting its importance in reducing mortality and healthcare costs.
- Following established guidelines, the research included 110 records of 27 different PROMs, reviewed for their measurement properties over the years 1986 to 2023, mainly from the US and published in English.
- None of the PROMs were classified as highly trustworthy for use, with some deemed unsuitable, while 21 others showed potential for recommendation based on their measurement quality.
Background: Previous studies have suggested the utility of an indocyanine green plasma clearance rate of the future liver remnant (FLR) (ICGK-F) ≥0.05 in hepatobiliary resection to reduce the surgical risk. The present study aimed to verify whether future liver remnant size rather than ICGK-F matters in extended hepatobiliary resection.
View Article and Find Full Text PDFThe precise pathogenesis of Kawasaki disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3.
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- Allergic diseases are highly prevalent globally, yet prior research has not focused on the genetic factors behind sensitization to specific allergen components through genome-wide association studies (GWAS).
- The study aimed to identify genetic variants linked to immune responses against various allergen components by analyzing participants from the Tokyo Children's Health, Illness, and Development study, measuring IgE levels at age 9.
- Results indicated significant genetic associations with specific allergen sensitizations, particularly involving genes on chromosomes 14 and 6, marking the first evidence of genetic risk related to allergen component sensitization.
Dietary quality and eating behaviors are essential to evaluating bariatric surgery candidates. The Rapid Eating Assessment for Participants-Short Form (REAP-S) is a previously validated measure of dietary quality suited for use in primary care. This study aimed to evaluate the psychometric properties of the REAP-S in a pre-surgical bariatric population.
View Article and Find Full Text PDFBackground: Ambivalence towards food and diet, which favours behavioural inertia, might be a barrier to adopting healthier eating behaviours. Measuring it can help researchers to better understand its relationship with behaviour change and design interventions aimed at resolving it. In this scoping review, we map and describe methods and tools employed in studies to assess, measure or classify the ambivalence of participants towards food- and diet-related attitude objects.
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- In certain genetic cases, a second-hit mutation can occur in an embryo, leading to a condition called superimposed mosaicism, where both healthy and defective copies of a gene are present.
- The study reports two unrelated cases of Hailey-Hailey disease (HHD) exhibiting this type of mosaicism, where one case had a new, inherited mutation and the other involved a father with the variant but no symptoms.
- Both cases highlight that superimposed mosaicism can occur without a known family history of the disease, stressing the importance of genetic analysis for accurately diagnosing and assessing familial risks.