Synopsis of recent research by authors named "Daisaku Ozawa"
- Daisaku Ozawa's recent research primarily investigates the molecular mechanisms involved in the pathogenesis of neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis (ALS), focusing on protein aggregation phenomena and the role of lipid interactions.
- His studies reveal how the interaction of α-synuclein with lipids contributes to its aggregation in Parkinson’s disease, and the regulatory effects of RNA-binding proteins on RAN translation related to GGGGCC repeat expansions in ALS/FTD.
- Ozawa also explores amyloid aggregation and modulation, detailing how various factors like structural conversions and extracellular chaperones influence the formation and destabilization of amyloid fibrils related to diseases such as Alzheimer’s and dialysis-related amyloidosis.
