Amount of N(omega)-(Carboxymethyl)arginine generated in collagen and bovine serum albumin during glycation reactions is significantly different.

N(omega)-(Carboxymethyl)arginine (CMA), an advanced glycation end product (AGE), is found in glycated type I collagen. The levels of CMA generated in collagen and bovine serum albumin (BSA) were compared during in vitro glycation reactions. CMA production increased in collagen during incubation with glucose or ribose, attaining a molar quantity approximately the same as that of N(epsilon)-(carboxymethyl)lysine (CML), the dominant AGE.