Publications by authors named "Daiqin Bao"
Background: Recent studies have implicated a role for perioperative medications in determining patient outcomes after surgery for malignant tumours, including relapse and metastasis.
Methods: A combined approach spanned molecular, cellular, and organismal levels, including bioinformatics, immunohistochemical staining of clinical and animal samples, RNA sequencing of glioblastoma multiforme (GBM) cells with Ingenuity Pathway Analysis, lentiviral-mediated gene expression modulation, in vitro cell experiments, and in vivo orthotopic tumour transplantation.
Results: We observed a significant correlation between increased kappa opioid receptor (KOP receptor) expression and better prognosis in patients with glioma.
Sepsis is a critical condition characterized by a systemic inflammatory response to infection, often leading to severe vascular dysfunction and high mortality. One of the hallmarks of vascular dysfunction in sepsis is increased vascular permeability and the loss of pericytes, which are essential for maintaining vascular integrity. Despite the significance of pericyte loss in sepsis, the primary type of cell death responsible and the underlying molecular mechanisms remain incompletely understood.
View Article and Find Full Text PDFBackground: This study aimed to discover diagnostic and prognostic biomarkers for sepsis immunotherapy through analyzing the novel cellular death process, cuproptosis.
Methods: We used transcriptome data from sepsis patients to identify key cuproptosis-related genes (CuRGs). We created a predictive model and used the CIBERSORT algorithm to observe the link between these genes and the septic immune microenvironment.
Article Synopsis
- Sepsis is a serious illness that can cause multiple organ problems and affects how well patients do; understanding why this happens is important for treatment.
- Researchers looked at blood samples from sepsis patients to find important genes related to blood clotting and created a way to predict how likely a patient is to survive.
- They discovered four key genes that can help predict survival chances, and found differences in immune system behavior depending on these genes in patients with sepsis.
Radix Sanguisorbae Improves Intestinal Barrier in Septic Rats via HIF-1 α/HO-1/Fe Axis.
Chin J Integr Med
December 2024
Objective: To investigate whether Radix Sanguisorbae (RS, Diyu) could restore intestinal barrier function following sepsis using a cecal ligation and puncture (CLP)-induced septic rat model and lipopolysaccharide (LPS)-challenged IEC-6 cell model, respectively.
Methods: Totally 224 rats were divided into 4 groups including a control, sham, CLP and RS group according to a random number table. The rats in the control group were administrated with Ringer's lactate solution (30 mL/kg) with additional dopamine [10 µ g/(kg·min)] and given intramuscular injections of cefuroxime sodium (10 mg/kg) 12 h following CLP.
Article Synopsis
- Scientists wanted to find special genes related to fat processing that cause problems in the immune system during sepsis (a serious infection).
- They used smart computer programs to analyze these genes and studied how they affected immune cells in sick people compared to healthy ones.
- They discovered several important genes and found that changing their activity could help reduce inflammation and improve the health of sepsis patients.
Article Synopsis
- Researchers think that special cells called pericytes help protect blood vessels during sepsis, which is a serious infection that can harm the body.
- In their experiments, they used mice and rats to see how losing pericytes affects blood vessel function during sepsis.
- They found that adding pericytes back improved the blood vessels' ability to work properly and stay strong, showing that these cells play an important role in keeping us healthy during infections.
Background: Myocardial dysfunction played a vital role in organ damage after sepsis. Fluid resuscitation was the essential treatment in which Lactate Ringer's solution (LR) was commonly used. Since LR easily led to hyperlactatemia, its resuscitation effect was limited.
View Article and Find Full Text PDFBackground: The mortality of trauma combined with seawater immersion is higher than that of land injury, however, research on how to treat this critical case and which treatments to adopt is lacking.
Methods: The effect of the thiol compound, N-acetyl-L-Cysteine (NAC), on survival, acidosis, coagulopathy, vital signs, oxidative stress, and mitochondrial and multi-organ function was assessed in a rat model of hemorrhagic shock combined with seawater immersion (Sea-Shock).
Results: Hemorrhagic shock combined with seawater immersion caused a severe lethal triad: multi-organ impairment, oxidative stress, and mitochondrial dysfunction.