Publications by authors named "Dain Kang"
Purpose: Women are experiencing reproductive health abnormalities at younger ages, and the incidence of cervical cancer in women in their 20s and 30s is increasing. Various factors hinder visits to obstetrics and gynecology. This cross-sectional study aimed to explore how health knowledge, reproductive health-promoting behavior, and sexual communication influenced the degree of intention to visit obstetrics and gynecology in unmarried women.
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- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) shows promise as a cure for myelodysplastic neoplasms (MDSs) and other blood cancers.
- A study of 21 MDS patients post-transplantation revealed 38% developed new genetic mutations, indicating clonal hematopoiesis (CH) from donor cells and a higher incidence of CH compared to healthy individuals.
- Additionally, telomere length in these patients shortened significantly, suggesting stress and rapid cell division in the new bone marrow environment may accelerate genetic changes.
Recent advancements in spin-orbit torque (SOT) technology in two-dimensional van der Waals (2D vdW) materials have not only pushed spintronic devices to their atomic limits but have also unveiled unconventional torques and novel spin-switching mechanisms. The vast diversity of SOT observed in numerous 2D vdW materials necessitates a screening strategy to identify optimal materials for torque device performance. However, such a strategy has yet to be established.
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- - The study focuses on a unicellular protist that can learn and remember its environment, despite lacking a brain or nervous system, which has made it an interesting subject for various scientific studies.
- - Researchers developed a method using hydrophobic lines and patterns to control the protist's movement, testing different barrier designs to effectively guide its propulsion and navigation.
- - By implementing these geometric constraints, they significantly reduced the time needed for toxicity testing, cutting it by over 300%, and opened up new avenues for studying the protist's biophysical properties and behaviors.
Article Synopsis
- Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries but is rare in Asia, leading to limited genetic studies in this region.
- This research focused on genetically analyzing 113 CLL patients from Korea using next-generation sequencing, discovering that mutations such as L265P and V217F were prevalent.
- The study found that patients with certain genetic conditions, like somatic hypermutation (SHM) and specific mutations, had better treatment outcomes and overall survival compared to those without these features.
[Do taegyo practices, self-esteem, and social support affect maternal-fetal attachment in high-risk pregnant women? A cross-sectional survey].
Korean J Women Health Nurs
December 2022
Purpose: The incidence of high-risk pregnancies is increasing in Korea as the birth age increasesdue to late marriage. Maternal-fetal attachment is an important factor that affects children even afterchildbirth, but it is difficult for high-risk pregnant women to form maternal-fetal attachment. Thecurrent study aimed to explore whether taegyo practice (i.
View Article and Find Full Text PDFThe in-frame internal tandem duplication (ITD) of the FMS-like tyrosine kinase 3 () gene is an important negative prognostic marker in acute myeloid leukemia (AML). -ITD monitoring is essential for patients at relapse or those receiving -targeted therapies. Fragment analysis (FA) is commonly used to detect and quantify -ITDs; however, detecting low-burden -ITDs after a treatment is challenging.
View Article and Find Full Text PDFRecent studies demonstrated a significant role of several microRNAs (miRs) in the development of leiomyoma. Here, we investigated miR expression profiles using microarray and found a significantly higher expression of miRs in leiomyoma than in adjacent myometrium. We also confirmed the upregulation of five selected miRs including miR-181a-5p, 127-3p, 28-3p, 30b-5p and let-7c-5p in cellular proliferation, extracellular matrix turnover, and angiogenesis by RT-qPCR.
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- The study investigates genetic abnormalities in 45 patients with acute myeloid leukemia with myelodysplasia-related changes (AML-MRC), focusing on gene fusions and mutations.
- It identifies four gene fusions and 81 somatic mutations, with TP53 being the most common mutation related to poor survival outcomes.
- Additional mutations (ASXL1 and SRSF2) are noted as potential diagnostic markers for AML-MRC, highlighting their significance in assessing the severity and treatment strategies for the condition.
Characteristics of amniotic mesenchymal stromal cells derived from term and preterm labor.
Taiwan J Obstet Gynecol
January 2022
Article Synopsis
- The study investigates the gene expression profiles of amniotic mesenchymal stromal cells (AMSCs) obtained from preterm and term labor to understand their differences and similarities.
- Researchers isolated AMSCs from 43 placentas and conducted microarray analysis, revealing that preterm AMSCs showed different gene expression patterns related to inflammation and cellular processes compared to term AMSCs.
- The findings suggest that increased expression of the CDKN2A gene in AMSCs may be linked to placental aging and labor, marking a significant contribution to understanding labor mechanisms.
Article Synopsis
- Juvenile myelomonocytic leukaemia (JMML) is a rare childhood blood disorder that presents challenges in diagnosis due to its varied symptoms and clinical progression.
- A study analyzed 24 JMML patients, revealing that 88% had RAS pathway mutations, with common genes affected including PTPN11 and NRAS.
- The overall 5-year event-free survival rate was around 58.9%, with NRAS positive patients showing better survival outcomes compared to other genetic profiles.
-positive acute leukemia can be classified into three disease categories: B-lymphoblastic leukemia (B-ALL), acute myeloid leukemia (AML), and mixed-phenotype acute leukemia (MPAL). We conducted an integrative analysis of RNA sequencing (RNA-seq) data obtained from 12 -positive B-ALL, AML, and MPAL samples to evaluate its diagnostic utility. RNA-seq facilitated the identification of all p190 with accurate splicing sites and a new gene fusion involving .
View Article and Find Full Text PDFGiven limited studies on next-generation sequencing-based measurable residual disease (NGS-MRD) in acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), we longitudinally collected samples before and after allo-HSCT from two independent prospective cohorts (n = 132) and investigated the prognostic impact of amplicon-based NGS assessment. Persistent mutations were detected pre-HSCT (43%) and 1 month after HSCT (post-HSCT-1m, 20%). All persistent mutations at both pre-HSCT and post-HSCT-1m were significantly associated with post-transplant relapse and worse overall survival.
View Article and Find Full Text PDFIntroduction: The single most common cause of miscarriage is genetic abnormality.
Objective: We conducted a prospective cohort study to compare the performance of conventional karyotyping and chromosomal microarray analysis (CMA) using array comparative genomic hybridization (array-CGH) and single nucleotide polymorphism array (SNP-array) to identify genetic abnormalities in miscarriage specimens.
Methods: A total of 63 miscarriage specimens were included.
Background: Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer-related deaths worldwide, and an accurate and non-invasive biomarker for the early detection and monitoring of HCC is required. We assessed pathogenic variants of HCC driver genes in cell-free DNA (cfDNA) from HCC patients who had not undergone systemic therapy.
Methods: Plasma cfDNA was collected from 20 HCC patients, and deep sequencing was performed using a customized cfDNA next-generation sequencing panel, targeting the major HCC driver genes (, , ) that incorporates molecular barcoding.
Introduction: Next-generation sequencing (NGS) panels have recently been introduced to efficiently detect genetic variations in hematologic malignancies.
Objectives: Our aim was to evaluate the performance of the commercialized Oncomine™ myeloid research assay (OMA) for myeloid neoplasms.
Methods: Certified reference materials and clinical research samples were used, including 60 genomic DNA and 56 RNA samples.
Objective: The objective of this study was to explore characteristics of bone marrow mesenchymal stromal cells (BM-MSCs) derived from patients with myelodysplastic syndrome (MDS) and multiple myeloma (MM).
Methods: BM-MSCs were recovered from 17 of MDS patients, 23 of MM patients and 9 healthy donors and were passaged until proliferation stopped. General characteristics and gene expression profiles of MSCs were analysed.
Objective: Short tandem repeat (STR) loci are most frequently used for chimerism analysis after hematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate the practical informativeness of STR chimerism by integrating theoretical and analytical points.
Methods: Theoretical and practical informativess of 16 STR loci were evaluated from 1249 pairs of recipients and donors who were prepared for HSCT.