Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson's disease.

Introduction: Melanoma, a highly aggressive form of skin cancer, and Parkinson's disease (PD), a progressive neurodegenerative disorder, have been epidemiologically linked, showing a positive association that suggests a shared etiology. This association implies that individuals with one condition may have an increased risk of developing the other. However, the specific molecular mechanisms underlying this relationship remain unclear.

A new online detection method of tobacco impurities for tobacco robot.

In the tobacco industry, impurity detection is an important prerequisite for ensuring the quality of tobacco. However, in the actual production process, the complex background environment and the variability of impurity shapes can affect the accuracy of impurity detection by tobacco robots, which leads to a decrease in product quality and an increase in health risks. To address this problem, we propose a new online detection method of tobacco impurities for tobacco robot.

Research Status and Development Trend of Coal Spontaneous Combustion Fire and Prevention Technology in China: A Review.

Coal seam spontaneous combustion fire is not only one of the main forms of the five major mine disasters, but also the main cause of secondary disasters such as mine gas and coal dust explosions. In recent years, with the advancement of mechanization, automation, and intelligent mine construction, spontaneous coal fires in mines have presented a series of new characteristics, and the prevention and control of spontaneous coal fires are also facing new challenges. On the basis of literature research, this paper summarizes and discusses the basic theory of coal spontaneous combustion, monitoring and early warning methods, and prevention and control technology, summarizes the development process of coal spontaneous combustion theory, reviews the research progress of coal spontaneous combustion monitoring and early warning methods and prevention and control technologies, and discusses the future development direction.

Study on Pyrolysis and Oxidation Characteristics of Coal Gangue Based on TGA-DSC.

Coal gangue spontaneous combustion has caused serious environmental and ecological problems. To investigate the reaction kinetic parameters of the gangue and the exothermic characteristics of the spontaneous combustion of the influence of the law, this study employs the thermogravimetric method to explore the characteristic parameters of the pyrolysis and oxidative combustion process of the gangue from the perspective of thermodynamics, and, at the same time, using the differential scanning calorimetry (DSC) on the exothermic effect of the gangue to explore the gangue to obtain the gangue and the original coal TG/DTG/DSC curves to be compared and from the perspective of thermodynamics. The change rule and potential parameters in the pyrolysis and oxidative combustion process of coal gangue (CG) were analyzed, the oxidation kinetic properties of CG were studied, and the reaction mechanism of oxidative spontaneous combustion of CG was further explained.

Structural insights in the permeation mechanism of an activated GIRK2 channel.

G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in physiopathology by the regulation of cell excitability. This regulation depends on the K ion conduction induced by structural constrictions: the selectivity filters (SFs), helix bundle crossings (HBCs), and G-loop gates. To explore why no permeation occurred when the constrictions were kept in the open state, a 4-K-related occupancy mechanism was proposed.

Degradation and dechlorination of trichloroacetic acid induced by an in situ 222 nm KrCl* excimer radiation.

Since the coronavirus disease 2019 (COVID-19) pandemic epidemic, the excessive usage of chlorinated disinfectants raised the substantial risks of disinfection by-products (DBPs) exposure. While several technologies may remove the typical carcinogenic DBPs, trichloroacetic acid (TCAA), their application for continuous treatment is limited due to their complexity and expensive or hazardous inputs. In this study, degradation and dechlorination of TCAA induced by an in situ 222 nm KrCl* excimer radiation as well as role of oxygen in the reaction pathway were investigated.

Accuracy of predicting metabolizable energy from in vitro digestible energy determined with a computer-controlled simulated digestion system in feed ingredients for ducks.

Two experiments were conducted to study the accuracy of predicting true metabolizable energy (TME) of ingredients for ducks from in vitro digestible energy (IVDE) determined with a computer-controlled simulated digestion system. Experiment 1 was to establish TME prediction models from the IVDE of 9 energy feed ingredients and 12 protein feed ingredients using regression analysis. Experiment 2 was to validate the accuracy of the predicted ME of 10 ingredients randomly selected from Exp.

Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices.

Background: The presence of ketone bodies (KBs) can interfere with creatinine (Cr) measurement in both enzymatic and Jaffe methods. Since a high proportion of children hospitalized for diabetic ketoacidosis (DKA) develop acute kidney injury (AKI), here we investigate whether KB interferences affect the accuracy of pediatric Cr measurement.

Methods: Residual patient plasma samples were pooled to make three Cr levels (~ 50, 100, and 250 μM).

An Easily Fabricated High Performance Fabry-Perot Optical Fiber Humidity Sensor Filled with Graphene Quantum Dots.

An easily fabricated Fabry-Perot optical fiber humidity sensor with high performance was presented by filling Graphene Quantum Dots (GQDs) into the Fabry-Perot resonator, which consists of two common single mode optical fibers. The relative humidity sensing performance was experimentally investigated by an interference spectrum drift between 11 %RH to 85 %RH. 0.

Permeation mechanisms through the selectivity filter and the open helix bundle crossing gate of GIRK2.

G protein-gated inwardly rectifying potassium channels (GIRK) are essential for the regulation of cellular excitability, a physiological function that relies critically on the conduction of K ions, which is dependent on two molecular mechanisms, namely selectivity and gating. Molecular Dynamics (MD) studies have shown that K conduction remains inefficient even with open channel gates, therefore further detailed study on the permeation events is required. In this study, all-atom MD simulations were employed to investigate the permeation mechanism through the GIRK2 selectivity filter (SF) and its open helix bundle crossing (HBC) gate.

Inactivation of antibiotic resistant Escherichia coli and degradation of its resistance genes by glow discharge plasma in an aqueous solution.

Emerging contaminants such as antibiotic resistance bacteria (ARB) and antibiotic resistance genes (ARGs) are becoming a global environmental problem. In this study, the glow discharge plasma (GDP) was applied for degrading antibiotic resistant Escherichia coli (E. coli) with resistance genes (tetA, tetR, aphA) and transposase gene (tnpA) in 0.

On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer.

G protein-gated inwardly rectifying K (GIRK) channels belong to the inward-rectifier K (Kir) family, are abundantly expressed in the heart and the brain, and require that phosphatidylinositol bisphosphate is present so that intracellular channel-gating regulators such as Gβγ and Na ions can maintain the channel-open state. However, despite high-resolution structures (GIRK2) and a large number of functional studies, we do not have a coherent picture of how Gβγ and Na ions control gating of GIRK2 channels. Here, we utilized computational modeling and all-atom microsecond-scale molecular dynamics simulations to determine which gates are controlled by Na and Gβγ and how each regulator uses the channel domain movements to control gate transitions.

Near-infrared lateral photovoltaic effect of β-FeSi films on SrTiO substrate.

β-FeSi is of interest for Si-based optoelectronic applications in the past decades. We fabricated β-FeSi thin films on the SrTiO single crystal by KrF-pulsed laser deposition to open a new view of integrating β-FeSi with non-silicon functional materials. After investigating the lateral photovoltaic effect of β-FeSi/SrTiO under the illumination of the 808 nm and 1064 nm steady lasers, we found that the position detection sensitivity can reach 2.

Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway.

Objective: We aimed to find out the underlying mechanism of forskolin (Fsk) and 3-isobutyl-1-methylxanthine (IBMX) on glioma stem cells (GSCs).

Methods: The expression of cAMP-related protein CREB and pCREB as well as apoptosis-related proteins were detected through Western blot analysis. The level of proliferation and growth rate of human GSCs was measured through thiazolyl blue tetrazolium bromide assay and stem cells forming sphere assay.

Candidate recommendations for protein electrophoresis reporting from the Canadian Society of Clinical Chemists Monoclonal Gammopathy Working Group.

Protein electrophoresis is commonly used as an aid in the diagnosis of monoclonal gammopathies and is performed in many laboratories in Canada and throughout the world. However, unlike many other diagnostic tests, there is limited guidance for standardization and neither guidance nor specific recommendations for clinical reporting of serum (SPE) or urine (UPE) protein electrophoresis and immunotyping available in the literature. Therefore, a Canadian effort was undertaken to recommend standards that cover all aspects of clinical reporting with an ultimate goal towards reporting standardization.

[Comparative Analysis of the Bacterial Community on Anodic Biofilms in Sediment Microbial Fuel Cell Under Open and Closed Circuits].

To investigate the differences in microbial community of anodic biofilms under open and closed circuits, sediment microbial fuel cell (SMFCs) reactors connecting with a 5 kΩ external resistance and open circuit during the start-up period were operated individually. Anodic biofilms were collected and analyzed using Solexa high-throughput sequencing technology. A total of 3936 and 3930 operational taxonomic units (OTUs) were obtained from the anodic biofilms under open and closed circuits, respectively.

Malignant catatonia mimicking pheochromocytoma.

Malignant catatonia is an unusual and highly fatal neuropsychiatric condition which can present with clinical and biochemical manifestations similar to those of pheochromocytoma. Differentiating between the two diseases is essential as management options greatly diverge. We describe a case of malignant catatonia in a 20-year-old male who presented with concurrent psychotic symptoms and autonomic instability, with markedly increased 24-hour urinary levels of norepinephrine at 1752 nmol/day (normal, 89-470 nmol/day), epinephrine at 1045 nmol/day (normal, <160 nmol/day), and dopamine at 7.

Phase stitching and error correction in aperture synthesis for generalized phase-shifting interferometry.

An accurate aperture synthesis method in generalized phase-shifting interferometry is suggested to improve the quality of the reconstructed object wavefront by stitching both the phase and the real amplitude of the object wave on the recording plane. Since the phase distribution affects the reconstruction of the original object wavefront, phase stitching is also important in aperture synthesis. Double correlations are used to find the proper relative locations and correct the phase error of subwavefronts on the recording plane.

Bis(9-allyl-6-carb-oxy-9H-carbazole-3-carboxyl-ato-κ(2) O (3),O (3'))diaqua-zinc.

In the title compound, [Zn(C17H12NO4)2(H2O)2], the Zn(II) atom is located on a twofold rotation axis and is six-coordinated by four carboxyl-ate O atoms from two chelating 9-allyl-6-carb-oxy-9H-carbazole-3-carboxyl-ate ligands and two O atoms from two water mol-ecules. In the crystal, O-H⋯O hydrogen bonds link the mol-ecules into a layer structure parallel to (-101).

The selenium deficiency disease exudative diathesis in chicks is associated with downregulation of seven common selenoprotein genes in liver and muscle.

Fast-growing broiler chicks are susceptible to Se deficiency diseases including exudative diathesis (ED). Our objective was to determine if ED could be induced by feeding a current, practical diet and if the incidence was related to selenogenome expression in liver and muscle of chicks. Four groups of day-old broiler chicks (n = 60/group) were fed a corn-soy basal diet (BD; 14 μg Se/kg; produced in the Se-deficient area of Sichuan, China and not supplemented with Se or vitamin E), the BD and all-rac-α-tocopheryl acetate at 50 mg/kg and Se (as sodium selenite) at 0.

[New method for wave-plate orientation determination based on the shape of the modulated spectrum].

A new method for the determination of fast axis of wave-plate is introduced. Based on the principle of electro-optic phase compensation in the wave-plate phase measuring method, the relation between the polarization extinction system out-put signal and the modulating signal can be acquired through the composition of frequency fixed alternating voltage modulation signal. Through the analysis of this process with Jones matrix, the out-put signal was usually found to be the composition of fundamental frequency and second harmonic frequency, the composition signal reflects the axis information as well as the phase information of the wave-plate, and this phenomenon has never been noticed before.

Precise analysis of combination homogeneous-inhomogeneous-material superresolution filters with double-tunable modes.

By using a Jones matrix, the precise expression for the pupil function of a two-adjustable-mode superresolving filter, a combination of a radial birefringent plate and a glass annular plate, is obtained. This filter can provide superresolution in both radial and axial adjustment operations, which can supplement each other in setting accuracy and superresolution range in practical use. As an adjustable filter, it is less dependent on wavelength.

Incomplete pediatric reference intervals for the management of patients with inborn errors of metabolism.

Objectives: To evaluate the status of pediatric reference intervals for several biomarkers of inborn errors of metabolism (IEM).

Introduction: There are several biomarkers that are used in many laboratories that specialize in biochemical genetics. Among them, there are acylcarnitines, total carnitine, amino acids, essential fatty acids, phytanic acid and very long chain fatty acids.