Publications by authors named "Daiki Matsuoka"
Article Synopsis
- Red complex bacteria are highly virulent in periodontal disease, and this study focused on their relationships with other oral bacteria in older Japanese individuals.
- Polymerase chain reaction was used to analyze dental plaque from 116 subjects, finding that individuals positive for red complex bacteria had significantly higher detection rates of certain periodontal pathogens compared to those who were negative.
- The findings indicate that individuals harboring all three red complex species have a unique oral microbiome, showcasing greater α-diversity and lower β-diversity, suggesting they may be more prone to developing periodontal disease.
IgA nephropathy (IgAN), the most common primary glomerulonephritis, is considered an intractable disease with unknown pathogenic factors. In our previous study, Streptococcus mutans, the major causative bacteria of dental caries, which expresses Cnm, was related to the induction of IgAN-like nephritis. In the present study, the Cnm-positive S.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between the bacterial pathogen Porphyromonas gingivalis and the development of IgA nephropathy (IgAN) in patients, particularly focusing on the role of galactose-deficient IgA1 (Gd-IgA1).
- Saliva samples from IgAN patients showed higher levels of Gd-IgA1 compared to chronic kidney disease (CKD) patients, indicating a potential connection to P. gingivalis presence.
- IgAN patients with detectable P. gingivalis also exhibited significantly increased Gd-IgA1 and protein levels in urine, and more severe kidney damage as evident from renal biopsy findings, suggesting that P. gingivalis may contribute to IgAN
The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S.
View Article and Find Full Text PDFCnm of is important for cell surface structure and membrane permeability.
Front Cell Infect Microbiol
October 2022
, a Gram-positive facultative anaerobic bacterium, is a major pathogen of dental caries. The protein Cnm of is involved in collagen binding, but its other biological functions are unknown. In this study, a Cnm-deficient isogenic mutant and a complementation strain were generated from a Cnm-positive strain to help determine the properties of Cnm.
View Article and Find Full Text PDFBackground: The simultaneous presence of Streptococcus mutans expressing the Cnm protein encoded by cnm (i.e., cnm-positive S.
View Article and Find Full Text PDFThe mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S.
View Article and Find Full Text PDF