Publications by authors named "Daijie Fu"
Article Synopsis
- Osteoarthritis affects many middle-aged and elderly individuals, resulting in various issues like unclear causes, poor prognosis, and frequent recurrences that harm both physical and mental health.
- Currently, treatment primarily focuses on symptom relief rather than addressing the underlying causes, highlighting the urgent need for further research.
- This study used protein omics to discover that aging leads to excessive sulfur oxidation in chondrocytes, triggering inflammation and suggesting new pathways for targeted treatments.
Ursolic acid (UA), found widely in nature, exerts effective anti-tumoral activity against various malignant tumors. However, the low water solubility and poor bioavailability of UA have greatly hindered its translation to the clinic. To overcome these drawbacks, a simple redox-sensitive UA polymeric prodrug was synthesized by conjugating UA to polyethylene glycol using a disulfide bond.
View Article and Find Full Text PDFShikonin has previously been shown to have antitumor, anti-inflammatory, antiviral and extensive pharmacological effects. The aim of the present study was to explore whether the protective effect of shikonin is mediated via the inhibition of inflammation and chondrocyte apoptosis, and to elucidate the potential molecular mechanisms in a rat model of osteoarthritis. A model of osteoarthritis was established in healthy male Sprague-Dawley rats and 10 mg/kg/day shikonin was administered intraperitoneally for 4 days.
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