Publications by authors named "Daihong Chen"
Background: HIV-1 drug resistance is a huge challenge in the era of ART.
Objectives: To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China.
Methods: An epidemiological study was performed among people living with human immunodeficiency virus (PLWH) receiving ART in Shanghai from January 2017 to December 2021.
Background: Inactivated COVID-19 vaccines are safe and effective in the general population with intact immunity. However, their safety and immunogenicity have not been demonstrated in people living with HIV (PLWH).
Methods: 42 HIV-1 infected individuals who were stable on combination antiretroviral therapy (cART) and 28 healthy individuals were enrolled in this open-label two-arm non-randomized study at Hubei Provincial Center for Disease Control and Prevention, China.
The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elucidated. The present study analyzed maximal and early (within 10 days after disease onset) concentrations of 12-plex cytokines in plasma.
View Article and Find Full Text PDFThis study aimed to compare the performance of the BD FACSPresto system with the conventional standard-of-care technologies for the measurement of absolute CD4 count (AbsCD4), CD4 percentage (CD4%) and total hemoglobin concentration (Hb) in capillary and venous blood samples of HIV-negative and HIV-positive subjects. A total of 1304 participants were included in this prospective cohort study. Both venous and capillary blood samples were analyzed using the BD FACSPresto system and the results were compared against the BD FACSCalibur for enumerating AbsCD4 and CD4% and Sysmex XT-4000i hematology analyzer for determining Hb levels.
View Article and Find Full Text PDFArticle Synopsis
- Cryptococcal meningitis (CM) is a serious global disease affecting both HIV-infected and previously healthy patients, yet the immune responses in previously healthy patients (PHPs) are not well understood.
- A study analyzing 41 CM patients found that PHPs had higher counts of certain immune cells compared to non-PHPs, but similar levels of inflammatory markers, aside from lower immunoglobulin A (IgA) in non-PHPs.
- Despite PHPs having a higher five-year mortality rate than non-PHPs (22% vs. 12.5%), this difference was not statistically significant; however, higher immunoglobulin G (IgG) levels in serum during the disease onset may indicate increased mortality