A New Azaphilone From the Marine Sponge-Associated Fungus Botryosporium pulchrum.

A new azaphilone, botryazaphilone (1), the first example of azaphilone featuring a 6/6/5/5 tetracyclic system, together with two known ones, chermesinone A (2) and perangustol B (3), had been obtained from the marine sponge-associated fungus Botryosporium pulchrum. The structure of 1 was elucidated through the analysis of spectroscopic data, whereas its absolute configuration was determined via single-crystal x-ray diffraction. It is the first report of the secondary metabolites isolated from the genus Botryosporium.

Two New Pairs of Enantiomeric Butenolides from the Marine Sponge Suberties sp.

Two new pairs of enantiomeric butenolides, (+)- and (-)-suberiteslide A, (+)- and (-)-subertieslide B had been obtained from the marine sponge Suberties sp. The structures with absolute configurations of these compounds were unequivocally determined by spectroscopic analyses and ECD (Electronic Circular Dichroism) method. It was the first separation of butenolides from the marine sponges of genus Suberites.

Caulerspiros A and B, a new pair of -tocopheroid isomers from the green alga var. .

Caulerspiros A () and B (), a new pair of -tocopheroid isomers, with five known compounds (-) were isolated from the green alga var. . Their structures were elucidated by the method of comprehensive spectroscopy.

Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents.

In this paper, eight new galaxamide analogues (~) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue displayed broad spectrum cytotoxic activity toward each tested cell line with IC values of 1.65 ± 0.

Three New Butenolides from the Green Alga Caulerpa racemosa var. turbinata.

Three new butenolides, caulerpalide A and a pair of enantiomers, (+)-caulerpalide B and (-)-caulerpalide B, together with seven known compounds, have been isolated from the green alga Caulerpa racemosa var. turbinata. All these structures were determined by spectroscopic techniques.

Acanthophoraine A, a new pyrrolidine alkaloid from the red alga .

A new pyrrolidine alkaloid, acanthophoraine A (), along with six known alkaloids (-), had been isolated from the red alga . The structures of these compounds were identified by spectroscopic analyses. The absolute configuration of was established by ECD calculation.