Publications by authors named "Daichi Toyama"

CPN-116 is a peptidic agonist that activates human neuromedin U receptor type 2 (NMUR2) but suffers from chemical instability due to inherent backbone isomerization on the Dap residue. To address this, a Leu-Dap-type ()-chloroalkene dipeptide isostere was synthesized diastereoselectively as a surrogate of the Leu-Dap peptide bond to develop a ()-chloroalkene analogue of CPN-116. The synthesized CPN-116 analogue is stable in 1.

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