Publications by authors named "Daibo Feng"
Article Synopsis
- * Researchers preconditioned infrapatellar fat pad MSCs with TNF-α, leading to a significant increase in exosome secretion and identified key signaling pathways involved in this process, specifically the PI3K/AKT pathway.
- * The efficacy of TNF-α preconditioned MSC-EXOs was tested in a mouse model of OA, where they were introduced into the joint to assess their effects on joint health and animal movement, revealing promising results for cartilage maintenance.
Joint diseases greatly impact the daily lives and occupational functioning of patients globally. However, conventional treatments for joint diseases have several limitations, such as unsatisfatory efficacy and side effects, necessitating the exploration of more efficacious therapeutic strategies. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have demonstrated high therapeutic efficacyin tissue repair and regeneration, with low immunogenicity and tumorigenicity.
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- Osteoarthritis (OA) is a common degenerative disease, particularly affecting the elderly, leading to severe functional impairment and disability.
- Natural products (NPs) from plants, animals, and microorganisms are being explored as promising treatments for OA, with research highlighting their impact on key signaling pathways related to inflammation and cell death.
- The review discusses NPs' therapeutic effects in animal models and clinical studies, while suggesting future research directions to enhance understanding and application of NPs in OA treatment.
Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain, disability and economic loss in patients. Post-traumatic OA (PTOA) is a subtype of OA, accounting for >12% of the overall burden of OA.
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