Ryanodine receptors drive neuronal loss and regulate synaptic proteins during epileptogenesis.

Status epilepticus (SE) is a clinical emergency that can lead to the development of temporal lobe epilepsy (TLE). The development and maintenance of spontaneous seizures in TLE are linked to calcium (Ca)-dependent processes such as neuronal cell loss and pathological synaptic plasticity. It has been shown that SE produces an increase in ryanodine receptor-dependent intracellular Ca levels in hippocampal neurons, which remain elevated during the progression of the disease.