Publications by authors named "Daiana Moreno"

Article Synopsis
  • * Traditional imaging techniques can help rule out conditions like urinary obstruction but still fall short in providing a clear diagnosis for the underlying causes of AKI.
  • * There is growing interest in developing new urine and blood biomarkers that could lead to better diagnostic tools, particularly for conditions like acute interstitial nephritis and damage from chemotherapy, which might significantly enhance patient care and outcomes.
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Background: Creatinine-based estimated glomerular filtration rate (eGFR) may overestimate kidney function in patients with sarcopenia. While cystatin C-based eGFR (eGFR) is less affected by muscle mass, it may underestimate kidney function in patients with obesity. We sought to evaluate the relationship between body composition defined by computed tomography (CT) scans and discordance between creatinine, eGFR and eGFR in adult patients with cancer.

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Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved overall and progression free survival of patients with metastatic breast cancer, but their effect on short and long-term kidney function is unknown. We found that early, mild estimated glomerular filtration rate (eGFR) decline was common in patients treated with CDK 4/6 inhibitors; however, severe kidney injury is rare and long-term eGFR decline is uncommon.

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Importance: Serum creatinine-based estimated glomerular filtration rate (eGFRcr) may overestimate the glomerular filtration rate (GFR) in patients with cancer. Cystatin C-based eGFR (eGFRcys) is an alternative marker of GFR.

Objective: To determine whether the therapeutic drug levels and adverse events (AEs) associated with renally cleared medications were higher in patients with cancer whose eGFRcys was more than 30% lower than their eGFRcr.

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Background: Sodium-glucose transporter 2 (SGLT2) inhibitors have been approved for treatment of diabetes mellitus (DM), chronic kidney disease, and heart failure, but little is known about prescription levels and safety profiles among people with HIV (PWH).

Methods: We leveraged data from the US Mass General Brigham electronic healthcare database to determine the use/uptake of SGLT2 inhibitors among PWH with type II diabetes (DM2) (with or without chronic kidney disease, proteinuria, or heart failure) and to assess rates of adverse events among PWH with DM2 taking SGLT2 inhibitors.

Results: Among eligible PWH with DM2 receiving care at US Mass General Brigham (N = 907), SGLT2 inhibitors were prescribed to 8.

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Background: Chronic kidney disease (CKD) is an important risk factor for mortality from COVID-19. Remdesivir has been shown to shorten time to recovery in patients with severe COVID-19. However, exclusion of patients with severe kidney function impairment in clinical trials has led to concerns about kidney safety of remdesivir in patients with pre-existing kidney disease.

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Background: Creatinine-based estimated glomerular filtration rate (eGFR) may overestimate kidney function in patients with cancer. Cystatin C-based eGFR (eGFR) is an alternative marker of kidney function. We investigated whether patients with an eGFR discrepancy, defined as eGFR >30% lower than the concurrent eGFR, had an increased risk of adverse events resulting from renally-cleared medications.

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Article Synopsis
  • Researchers are investigating non-invasive biomarkers to diagnose immune checkpoint inhibitor-associated acute tubulointerstitial nephritis (ICI-nephritis), focusing on markers of immune dysregulation linked to CTLA4 deficiency.
  • The study compared sIL-2R levels and cell-based markers from patients with ICI-nephritis against various control groups, revealing that sIL-2R levels were significantly elevated in patients with ICI-nephritis.
  • A specific sIL-2R cutoff of 1.75-fold above the normal limit was found to be a strong indicator for diagnosing ICI-nephritis.
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