"Bis-Clamp-Cavity Synergy", an Efficient Approach to Improve Guest Binding Properties of Macrocyclic Host and Its Application on Detection of Al and Arg in Living Cells.

Improving the selective and sensitive binding properties of macrocyclic hosts to target guests is always an interesting challenge. Herein, we introduce a novel "bis-clamp-cavity synergy" strategy to enhance the selectivity and binding sensitivity of pillararenes toward target guests. To achieve this goal, we designed and synthesized ,'-bis-hydroxynaphthoylhydrazone-functionalized conjugated pillar[5]arene (), in which bis-hydroxynaphthoylhydrazone plays the role of clamps, while the pillar[5]arene provides the macrocyclic cavity.

Rapid discrimination and quantification of chemotypes in Perillae folium using FT-NIR spectroscopy and GC-MS combined with chemometrics.

Perillae Folium (PF) is a well-known food and herb containing different chemotypes, which affect its quality. Herein, a method was proposed to classify and quantify PF chemotypes using gas chromatography-mass spectrometry (GC-MS) and Fourier transform-near infrared spectroscopy (FT-NIR). GC-MS results revealed that PF contains several chemotypes, including perilla ketone (PK) type, -asarone (PP-as) type, and dillapiole (PP-dm) type, with the PK type being the predominant chemotype.

Colloidal gold and fluorescent immunochromatographic test strips for canine parvovirus detection.

Canine parvovirus (CPV) is an acute and highly infectious virus causing disease in puppies and, thus, affecting the global dog industry. The current CPV detection methods are limited by their sensitivity and specificity. Hence, the current study sought to develop a rapid, sensitive, simple, and accurate immunochromatographic (ICS) test to detect and control the spread and prevalence of CPV infection.

Combining stable isotope, multielement and untargeted metabolomics with chemometrics to discriminate the geographical origins of ginger (Zingiber officinale Roscoe).

Ginger (Zingiber officinale Roscoe) is a high-value food and herb worldwide. The quality of ginger is often related to its production regions. In this study, stable isotopes, multiple elements, and metabolites were investigated together to realize ginger origin traceability.

Rapid detection of adulteration in powder of ginger ( Roscoe) by FT-NIR spectroscopy combined with chemometrics.

Ginger powder (GP) is a popular spice in the world. Duo to its nutritional value, GP is regarded as an attractive target for adulteration, which is not easily detected. In this study, chromaticity analysis and Fourier transform near-infrared (FT-NIR) spectroscopy combined with chemometrics were developed to identify and quantify of GP and its adulterants.

[Rapid identification of geographic origins of Zingiberis Rhizoma by NIRS combined with chemometrics and machine learning algorithms].

In this study, 280 batches of Zingiberis Rhizoma samples from nine producing areas were analyzed to obtain infrared spectral information based on near-infrared spectroscopy(NIRS). Pluralistic chemometrics such as principal component analysis(PCA), partial least squares-discriminant analysis(PLS-DA), orthogonal partial least squares-discriminant analysis(OPLS-DA), K-nearest neighbors(KNN), support vector machine(SVM), random forest(RF), artificial neural network(ANN), and gradient boosting(GB) were applied for tracing of origins. The results showed that the discriminative accuracy of the spectral preprocessing by standard normal variate transformation coupled with the first derivative was 93.

Headspace GC/MS and fast GC e-nose combined with chemometric analysis to identify the varieties and geographical origins of ginger (Zingiber officinale Roscoe).

Food authenticity regarding different varieties and geographical origins is increasingly becoming a concern for consumers. In this study, headspace gas chromatography-mass spectrometry (HS-GC-MS) and fast gas chromatography electronic nose (fast GC e-nose) were used to successfully distinguish the varieties and geographical origins of dried gingers from seven major production areas in China. By chemometric analysis, a distinct separation between the two varieties of ginger was achieved based on HS-GC-MS.

Specific Effects of Characteristics of Enriched Environment on Innovative Problem Solving by Animals.

Numerous studies have revealed that an enriched environment can enhance the survival-related behaviors and brain functions of animals. However, the effects and specific roles of the enrichment characteristics on animals' innovative capability, a cognitive ability crucial for survival in nature, are still not well known. In this study, we assigned mice to environment-manipulation groups ( = 15 each) to investigate the specific effects of environmental novelty (novel vs.

Comparison of Different Drying Methods on the Volatile Components of Ginger ( Roscoe) by HS-GC-MS Coupled with Fast GC E-Nose.

Ginger ( Roscoe) is one of the most popular spices in the world, with its unique odor. Due to its health benefits, ginger is also widely used as a dietary supplement and herbal medicine. In this study, the main flavor components of gingers processed by different drying methods including hot air drying, vacuum drying, sun-drying, and vacuum-freeze drying, were identified on the basis of headspace-gas chromatography coupled with mass spectrometry (HS-GC-MS) and fast gas chromatography electronic-nose (fast GC e-nose) techniques.

[Application and prospect of stable isotope technology in tracing geographical origin of Chinese herbal medicines].

As a unique medical resource in China, Chinese herbal medicine plays a key role in the prevention and treatment of human diseases. With the gradual expansion of applications, the quality of Chinese herbal medicine has become the focus of attention. The quality of Chinese herbal medicines depends largely on their source authenticity.

[Content and distribution of inorganic elements in Laminaria japonica based on ICP-MS and Micro-XRF].

In order to evaluate the composition and distribution characteristics of inorganic elements in Laminaria japonica, this study employed inductively coupled plasma mass spectrometry(ICP-MS) to detect the inorganic elements and used high performance liquid chromatography tandem ICP-MS(HPLC-ICP-MS) to determine the content of different arsenic species in L. japonica from diffe-rent origins. Micro X-ray fluorescence(Micro-XRF) was used to determine micro-area distribution of inorganic elements in L.

Geranylgeranyl transferase 1 inhibitor GGTI‑298 enhances the anticancer effect of gefitinib.

Dysregulation of epidermal growth factor receptor (EGFR) signaling is responsible for the resistance to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, and is thereby associated with the progression of tumors in non‑small cell lung cancers (NSCLCs). Immunoblotting results revealed that geranylgeranyl transferase 1 inhibitor (GGTI)‑298, a geranylgeranyl transferase 1 inhibitor with potential antitumor effects, effectively inhibited the phosphorylation of EGFR and its downstream target protein kinase B (AKT). A combination of gefitinib and GGTI‑298 amplified the inhibition of the EGFR‑AKT signaling pathway.

[Analysis of Factors Influencing Peripheral Blood Stem Cell Collection of 151 Lymphoma Cases].

Objective: To analyze the influential factors related to mobilization and collection of stem cells so as to improve the collection efficiency of autologous peripheral stem cell transplantation in lymphoma patients.

Methods: The peripheral blood stem cell collection data of 151 cases of lymphoma in our hospital was analyzed retrospectively. The relationship between the harvested CD34(+) stem cells and some factors, such as age, sex, height, weight, histological type, staging, mobilization programs, collecting days, blood transfusion, time and duration of chemotherapy, was analyzed.