Publications by authors named "Dai-Hui Peng"
Background: Neuroimmune plays an important role in major depressive disorders (MDD). N-linked protein glycosylation (NLG) might contribute to depression by regulating the neuroinflammatory response. As microglia is the main executor of neuroimmune function in the central neural system (CNS), targeting the process of N-linked protein glycosylation of microglia in the mice used for studying depression might potentially offer new avenues for the strategy for MDD.
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- Despite advancements in neuroimaging research on major depressive disorder (MDD), findings remain inconsistent due to small sample sizes and varying analysis methods, prompting the launch of the Depression Imaging REsearch ConsorTium (DIRECT) and the REST-meta-MDD project, which pooled data from 2,428 functional brain images.
- The initial analyses revealed significant changes in brain connectivity and dynamics, laying the groundwork for future research and highlighting the need for more comprehensive studies across diverse populations.
- DIRECT's second phase aims to broaden the investigation of brain alterations in MDD by including various ethnic groups and other mental health disorders, while also focusing on long-term studies of treatment effects and improving neuroimaging methodologies for clinical applications.
Article Synopsis
- The study investigates the nucleus accumbens (NAc), which is key in reward processing and its role in major depressive disorder (MDD).
- Through meta- and mega-analysis of resting-state fMRI data, it was found that patients with recurrent MDD exhibited decreased functional connectivity within the NAc-based reward circuits.
- The research highlights that disrupted connectivity between the reward network and the default mode network (DMN) may aid in differentiating MDD patients from healthy individuals, suggesting potential biomarkers for diagnosis.
Article Synopsis
- Deep brain stimulation (DBS) targeting the habenula (HB) shows promise in easing symptoms of treatment-resistant depression (TRD) and bipolar disorder (BD) in a pilot study involving seven patients.
- After one month, patients experienced significant reductions in depression and anxiety symptoms (around 49%), alongside improvements in overall health and quality of life, though results varied widely among participants.
- The study also found that changes in brain activity patterns correlated with symptom severity, suggesting that further research in larger studies is needed to confirm the safety and effectiveness of HB-DBS for mood disorders.
Article Synopsis
- The study investigates the alterations in functional homotopy architecture in patients with Major Depressive Disorder (MDD), highlighting a significant reduction in functional connectivity between homotopic brain regions.
- Using resting-state fMRI data from over 1,000 MDD patients and nearly 900 healthy controls, researchers found specific areas in the brain, like the posterior cingulate gyrus and precuneus, showed notably decreased connectivity in MDDs, with variations related to age and gender.
- The findings suggest that structural connectivity deficits in MDD may impact how information is exchanged between the brain's hemispheres, correlating with the severity of depressive symptoms and indicating potential areas for further study in treatment.
Brain structural alterations in MDD patients with gastrointestinal symptoms: Evidence from the REST-meta-MDD project.
Prog Neuropsychopharmacol Biol Psychiatry
December 2021
Article Synopsis
- This study aims to investigate the neural underpinnings of gastrointestinal (GI) symptoms in patients with major depressive disorder (MDD) by examining changes in brain structure, specifically focusing on gray matter volume (GMV) and density (GMD).* -
- Researchers divided participants into three groups: MDD patients with GI symptoms, MDD patients without GI symptoms, and healthy controls, analyzing MRI scans from a total of 930 individuals and using tools like the Hamilton Depression Rating Scale to assess symptoms.* -
- Results showed that patients with GI symptoms had higher depression scores and significant differences in brain structure compared to the other groups, particularly in regions like the superior temporal gyrus and caudate nucleus, suggesting a link between
Reduced NLRP3 inflammasome expression in the brain is associated with stress resilience.
Psychoneuroendocrinology
June 2021
Increased expression of the Nod-like receptor pyrin containing 3 (NLRP3) inflammasome and proinflammatory cytokines is associated with depressive behaviors. This study aimed to explore potential differences in neuroinflammation associated with stress resilience, as well as associated changes in autophagy, in a mouse model of chronic unpredictable mild stress (CUMS). Animals were classified as CUMS resilient or CUMS susceptible based on performance on behavioral tests following the CUMS protocol.
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- The study investigates brain functional connectivity asymmetry in patients with Major Depressive Disorder (MDD) using resting-state fMRI data from 753 patients compared to 451 healthy controls.
- Results show that MDD patients exhibited increased asymmetry scores, indicating decreased specialization in various brain networks, particularly in the default mode, control, and attention networks, influenced by demographic and clinical variables.
- The findings suggest that MDD disrupts efficient brain information processing, providing new insights into the pathophysiology of depression that could inform future research.
Article Synopsis
- Major depressive disorder (MDD) is complex and can be divided into subtypes based on differences in brain connectivity within the default mode network (DMN), as revealed by a study involving 1,397 participants (690 MDD patients and 707 healthy controls).
- Researchers used advanced data analysis methods, such as K-means and principal component analysis, to identify two distinct MDD subgroups—hyperDMN MDD (increased connectivity) and hypoDMN MDD (decreased connectivity)—which were consistently observed across multiple trials.
- The discovery highlights the importance of understanding these neural subtypes, potentially guiding more personalized treatments for individuals with depression based on their specific connectivity patterns.
Article Synopsis
- The study examines how functional neuroimaging differs in bipolar depression patients with anxiety symptoms (BDP-A) compared to those without (BDP-NA) and healthy controls (HC).
- Results showed that BDP-A patients had altered brain activity patterns, including decreased amplitude of low-frequency fluctuations in certain brain regions and increased functional connectivity.
- Limitations include a small sample size, the inclusion of non-drug-naive patients, a lack of pure anxiety disorder controls, and insufficient mental health evaluations of healthy participants.
Article Synopsis
- Major depressive disorder (MDD) is prevalent and disabling, with unclear underlying brain mechanisms; the REST-meta-MDD Project aims to address these knowledge gaps using a large data set.
- The project involved 25 research groups in China analyzing resting-state fMRI data from 1,300 MDD patients and 1,128 normal controls, finding decreased connectivity in the default mode network (DMN) among recurrent MDD patients.
- The study highlights the importance of DMN connectivity in MDD, revealing a relationship between decreased connectivity, medication usage, and symptom severity, while encouraging further research on the impact of these findings on treatment response.
Article Synopsis
- Nonadherence to treatment is a significant issue in managing major depressive disorder (MDD), and this study explores how various symptoms impact this issue based on a nationwide survey in China.
- The research involved 1,739 participants diagnosed with MDD who underwent a detailed questionnaire to evaluate their symptoms, employing logistic regression to analyze adherence factors.
- Findings indicate that certain elements, like recurrent episodes and specific antidepressant treatments, increase the likelihood of nonadherence, while others, like using SNRIs, can help protect against it, suggesting that clinicians should focus on these characteristics to improve treatment compliance.
Neuroimaging genomic studies in major depressive disorder: A systematic review.
CNS Neurosci Ther
November 2018
Genetic-neuroimaging studies could identify new potential endophenotypes of major depressive disorder (MDD). Morphological and functional alterations may be attributable to genetic factors that regulate neurogenesis and neurodegeneration. Given that the association between gene polymorphisms and brain morphology or function has varied across studies, this systematic review aims at evaluating and summarizing all available genetic-neuroimaging studies.
View Article and Find Full Text PDFBackground: With attention to misdiagnosis of bipolar disorder (BP), long duration of undiagnosed bipolar disorder (DUBP) had been reported recently in years. This study aims to investigate the contributions of long DUBP to the frequency of relapse in bipolar patients, and explore affect factors of DUBP.
Method: From 26 hospitals throughout China, 3896 participants diagnosed with BP according to International Classification of Diseases 10th criteria were enrolled in this study.
Background: Accumulating evidence suggests that altered immunity contributes to the development of major depressive disorder (MDD).
Aims: To examine whether complement factor H (CFH), a regulator of activation of the alternative pathway of the complement cascade, confers susceptibility to MDD.
Method: Expression analyses were tested in 53 unmedicated people with MDD and 55 healthy controls.
Increased cognition connectivity network in major depression disorder: a FMRI study.
Psychiatry Investig
April 2015
Objective: Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.
Methods: Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.
Objective: The association between a putative functional promoter polymorphism, -141C insertion/deletion (Ins/Del), in the dopamine receptor D2 gene (DRD2) and schizophrenia was investigated in a Chinese Han population.
Methods: The polymorphism was studied in unrelated schizophrenia patients and unrelated healthy controls. Linkage relationships were explored in core families of the schizophrenic patients using the transmission disequilibrium test.
Background: Reports on mood regulating circuit (MRC) indicated different activities between depressed patients and healthy controls. The functional networks based on MRC have not been described in major depression disorder (MDD). Both the anterior cingulate cortex (ACC) and thalamus are all the key regions of MRC.
View Article and Find Full Text PDFBackground: Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity (ReHo) in depression by resting-state functional magnetic resonance imaging (fMRI).
Methods: Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs.
[Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
February 2005
Objective: To investigate the association of -141C insert/delete polymorphism with schizophrenia in Wuhan of Hubei province.
Methods: A case-control study was conducted to analyze the polymorphism in the D(2) receptor gene promoter region with schizophrenia. A total of 120 cases of schizophrenia diagnosed according to CCMD-II R criteria and 100 normal controls were recruited in the study.