Ultrahigh Sensing Performance: Coresponse and Differentiation of Ethyl Acetate and Its Byproducts in Fe-Ce-O Interfacial Sensor.

Accurately detecting low concentrations of ethyl acetate (EA) holds promise for the early screening of rectal and gastric cancer. The primary challenges lie in achieving a high response at parts per billion level concentration and ensuring high selectivity. This study focuses on designing Fe-Ce-O bimetallic oxides with doping and heterogeneous interfaces, which exhibit outstanding redox properties and highly enhanced ability of the adsorption and activation of both O and EA molecules.

Qizhu Jianwei decoction triggers ferroptosis by exosome-mediated miR-199-3p/ACSL4 signaling pathways.

Ethnopharmacological Relevance: Qizhu Jianwei decoction (QZJWD) is a conventional Chinese medicine formulation used to treat gastric cancer, however, its association with GC and ferroptosis remains poorly understood.

Aim Of Study: Our research endeavors centered around investigating the potential molecular mechanism of QZJWD in suppressing GC.

Materials And Methods: A UHPLC-QTOF-MS technique was utilized for determining the major constituents of QZJWD.

Impact of bladder volume and bladder shape on radiotherapy consistency and treatment interruption in prostate cancer patients.

Background: To investigate the effect of bladder volume (BV) and bladder shape on consistency and treatment interruption in prostate cancer radiotherapy (RT).

Methods: A total of 275 patients who underwent radical prostate cancer RT in our institution from April 2015 to December 2022 were enrolled. Bladder height, bladder width, and bladder length were defined and recorded.

Biomimetic Sealing of Cisplatin by Cancer Cell Membranes to Achieve Nucleophile Resistance and Tumor Targeting for Improved Cancer Therapy.

Platinum-based anticancer drugs (PBCs), particularly cisplatin, play a key role in over 70% of cancer treatment protocols. PBCs suffer from their strong affinity with numerous nucleophiles present in the body, leading to significant systematic toxicity and rapid drug inactivation. The cell membrane's selective and energy-dependent transport properties, inherent to its unique biological structure, offer a strategic opportunity for employing cell membranes (CMs) in the development of PBC delivery systems that repel nucleophiles.

Electrospinning based biomaterials for biomimetic fabrication, bioactive protein delivery and wound regenerative repair.

Electrospinning is a remarkably straightforward and adaptable technique that can be employed to process an array of synthetic and natural materials, resulting in the production of nanoscale fibers. It has emerged as a novel technique for biomedical applications and has gained increasing popularity in the research community in recent times. In the context of tissue repair and tissue engineering, there is a growing tendency toward the integration of biomimetic scaffolds and bioactive macromolecules, particularly proteins and growth factors.

Cow Placenta Extract Ameliorates Cyclophosphamide-Induced Intestinal Damage by Enhancing the Intestinal Barrier, Improving Immune Function, and Restoring Intestinal Microbiota.

Immunosuppression undermines intestinal barrier integrity. Cow placenta extract (CPE) primarily consists of active peptides with immunomodulatory and antioxidant effects. This study aimed to examine the preventive effect of CPE against intestinal damage induced by cyclophosphamide (Cy) in immunosuppressed mice.

Generatable and Recyclable Oxygen Vacancy-Modified FeO-Decorated WO Nanowires with Super Stability for ppb-Level HS Sensing.

Detecting hydrogen sulfide (HS) odor gas in the environment at parts-per-billion-level concentrations is crucial. However, a significant challenge is the rapid deactivation caused by SO deposition. To address this issue, we developed a sensing material comprising FeO-decorated WO nanowires (FWO) with strong interfacial interaction.

Growth and development and trends in overweight and obesity among 7-12 years old Hmong children in China: an analysis of eight successive national surveys from 1985 to 2019.

Background: To explore the dynamic changes and trends in the body shape of Hmong children aged 7-12 years from 1985 to 2019, and to predict them, to provide a reference for the physical health level of Hmong children.

Methods: The body shape data of Hmong children aged 7-12 years old from the Chinese National Survey on Students' Constitution and Health (CNSSCH) in 1985, 1991, 1995, 2000, 2005, 2010, 2014, and 2019 were used for longitudinal comparative analysis, and the grey GM(1,1) model was established based on this as a time series. Forecast the future development trend in 2025 and 2030.

MFG-E8 Ameliorates Nerve Injury-Induced Neuropathic Pain by Regulating Microglial Polarization and Neuroinflammation via Integrin β3/SOCS3/STAT3 Pathway in Mice.

Spinal microglial polarization plays a crucial role in the pathological processes of neuropathic pain following peripheral nerve injury. Accumulating evidence suggests that milk fat globule epidermal growth factor-8 (MFG-E8) exhibits anti-inflammatory effect and regulates microglial polarization through the integrin β3 receptor. However, the impact of MFG-E8 on microglial polarization in the context of neuropathic pain has not yet been investigated.

Polymeric nanoformulations aimed at cancer metabolism reprogramming with high specificity to inhibit tumor growth.

Metabolic disorders of cancer cells create opportunities for metabolic interventions aimed at selectively eliminating cancer cells. Nevertheless, achieving this goal is challenging due to cellular plasticity and metabolic heterogeneity of cancer cells. This study presents a dual-drug-loaded, macrophage membrane-coated polymeric nanovesicle designed to reprogram cancer metabolism with high specificity through integrated extracellular and intracellular interventions.

Preparation of microspheres with sustained ketoprofen release by electrospray for the treatment of aseptic inflammation.

The treatment of aseptic inflammation has always been a clinical challenge. At present, non-steroidal drug-loaded microspheres have been widely used in the treatment of aseptic inflammation due to their excellent injectable and sustained release capabilities. In this study, ketoprofen-loaded shellac microspheres (Keto-SLAC) were prepared by electrospray.

Balancing the Binding of Intermediates Enhances Alkaline Hydrogen Oxidation on D-Band Center Modulated Pd Sites.

Exploring efficient alkaline hydrogen oxidation reaction (HOR) electrocatalysts is of great concern for constructing anion exchange membrane fuel cells (AEMFCs). Herein, d-band center modulated PdCo alloys with ultralow Pd content anchored onto the defective carbon support (abbreviated as PdCo/NC hereafter) are proposed as highly efficient HOR catalyst. The as-prepared catalyst exhibits exceptional HOR performance compared to the Pt/C catalyst, achieving thermodynamically spontaneous and kinetically preferential reactions.

Biogated mesoporous silica nanoagents for inhibition of cell migration and combined cancer therapy.

Migration is an initial step in tumor expansion and metastasis; suppressing cellular migration is beneficial to cancer therapy. Herein, we designed a novel biogated nanoagents that integrated the migration inhibitory factor into the mesoporous silica nanoparticle (MSN) drug delivery nanosystem to realize cell migratory inhibition and synergistic treatment. Antisense oligonucleotides (Anti) of microRNA-330-3p, which is positively related with cancer cell proliferation, migration, invasion, and angiogenesis, not only acted as the locker for blocking drugs but also acted as the inhibitory factor for suppressing migration via gene therapy.

Causality of genetically determined blood metabolites on irritable bowel syndrome: A Mendelian randomization study.

Background: Irritable bowel syndrome (IBS) is one of the most common functional bowel disorders and dysmetabolism plays an important role in the pathogenesis of disease. Nevertheless, there remains a lack of information regarding the causal relationship between circulating metabolites and IBS. A two-sample Mendelian randomization (MR) analysis was conducted in order to evaluate the causal relationship between genetically proxied 486 blood metabolites and IBS.

A study on mindful agency's influence on college students' engagement with online teaching: The mediating roles of e-learning self-efficacy and self-regulation.

Methodology: A total of 379 college students from 22 classes in 3 universities in Nanjing, who received online teaching, were selected as the participants in this study. The purpose of this thesis is to explore the influence mechanism of mindful agency on their identification by using the Mindful Agency Scale for College Students, the Scale for Identification of College Students with Online Teaching, the Online Learning Self-Efficacy Scale for Adult Learners, and the Questionnaire on Online Self-Disciplined Learning for College Students, which were proven effective in previous studies. In all these studies, the coefficients of Cronbach's α are all above 85.

Manipulation of Electronic States of Pt Sites via d-Band Center Tuning for Enhanced Oxygen Reduction Reaction in Proton Exchange Membrane Fuel Cells.

Expediting the torpid kinetics of the oxygen reduction reaction (ORR) at the cathode with minimal amounts of Pt under acidic conditions plays a significant role in the development of proton exchange membrane fuel cells (PEMFCs). Herein, a novel Pt-N-C system consisting of Pt single atoms and nanoparticles anchored onto the defective carbon nanofibers is proposed as a highly active ORR catalyst (denoted as Pt-N-C). Detailed characterizations together with theoretical simulations illustrate that the strong coupling effect between different Pt sites can enrich the electron density of Pt sites, modify the d-band electronic environments, and optimize the oxygen intermediate adsorption energies, ultimately leading to significantly enhanced ORR performance.