High transmission in 120-degree sharp bends of inversion-symmetric and inversion-asymmetric photonic crystal waveguides.

Bending loss is one of the serious problems for constructing nanophotonic integrated circuits. Recently, many works reported that valley photonic crystals (VPhCs) enable significantly high transmission via 120-degree sharp bends. However, it is unclear whether the high bend-transmission results directly from the valley-photonic effects, which are based on the breaking of inversion symmetry.

Photonic compressive sensing of microwave signals with enhanced compression ratio and frequency range via optical pulse random mixing.

We propose and demonstrate a photonic compressive sensing (PCS) scheme for microwave signals using optical pulse random mixing, significantly enhancing both the compression ratio and operating frequency range. Unlike continuous-wave laser-based PCS systems, our approach mitigates the non-ideal characteristics of the pseudo-random binary sequence (PRBS), such as sloped edges and amplitude jitters, resulting in a more ideal compression process. Additionally, the high harmonic components of the optical pulses further facilitate wideband downconversion, improving the system's operating frequency range.

First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation.

Introduction: Nasopharyngeal cancer (NPC) is a multifaceted disease characterized by genetic and epigenetic modifications. While Epstein-Barr virus (EBV) infection is a known risk factor, recent studies highlight the significant role of DNA methylation in NPC pathogenesis. Aberrant methylation, particularly at CpG sites, can silence tumour suppressor genes, promoting uncontrolled cell growth.

Integrated real-time intelligent control for wastewater treatment plants: Data-driven modeling for enhanced prediction and regulatory strategies.

Both mechanical models and machine learning-based models are widely utilized for real-time dynamic control; however, their implementation in the water sector often incurs significant data and computational costs. To address these challenges, this study introduces an innovative feature extraction method designed to enhance the cost-effectiveness of dynamic control in wastewater treatment plants. The proposed method extracts dynamic features from time-series data of key substrate variables to construct a data-driven model and develop real-time control strategies.

Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma.

Immune checkpoint inhibitors are not effective for metabolic dysfunction-associated fatty liver disease (MAFLD)-hepatocellular carcinoma (HCC) patients, and identifying the key gut microbiota that contributes to immune resistance in these patients is crucial. Analysis using 16S rRNA sequencing reveals a decrease in Akkermansia muciniphila (Akk) during MAFLD-promoted HCC development. Administration of Akk ameliorates liver steatosis and effectively attenuates the tumor growth in orthotopic MAFLD-HCC mouse models.

Comparative Analysis of the Chloroplast Genomes of the (Styracaceae) Species: Providing Insights into Molecular Evolution and Phylogenetic Relationships.

is a member of the Styracaceae family, which is well-known for its remarkable ornamental and medicinal properties. In this research, we conducted comparative analysis of the chloroplast genomes from four samples of representing . The results demonstrated that the chloroplast genome of four samples ranging from 157,103 bp to 158,357 bp exhibited a typical quadripartite structure, including one large single-copy (LSC) region (90,131 bp to 90,342 bp), one small single-copy (SSC) region (18,467 bp to 18,785 bp), and two inverted repeat regions (IRs) (24,115 bp to 24,261 bp).

Examining the influence of port ship activities on pollutant emissions in port environments.

There is a direct and close relationship between ship emissions in port waters and the operational status of the ships. Precisely identifying the operational status of ships in port waters and thoroughly exploring the specific relationship between these activities and ship emissions is crucial for achieving accurate control and scientific reduction of emissions from ships in port areas. With advancements in technology, AIS data can accurately capture the operational status of ships, facilitating a macro-level analysis of ship behavior and emission characteristics.

The Red Cell Distribution Width to Albumin Ratio: A Novel Prognostic Indicator in Hepatitis B Virus-Related Hepatocellular Carcinoma.

The prognostic significance of the red blood cell distribution width to albumin ratio (RAR) spans various diseases, yet its utility as a biomarker for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) remains unclear. We retrospectively studied 1,413 patients with HBV-HCC. Receiver operating characteristic curves identified optimal RAR cut-offs, stratifying patients into H-RAR and L-RAR groups.

Unveiling the nexus between irradiation and phase reconstruction in tin-lead perovskite solar cells.

Tin-lead perovskites provide an ideal bandgap for narrow-bandgap perovskites in all-perovskite tandem solar cells, fundamentally improving power conversion efficiency. However, light-induced degradation in ambient air is a major issue that can hinder the long-term operational stability of these devices. Understanding the specifics of what occurs during this pathway provides the direction for improving device stability.

Anomalous drainage of lingular vein into left inferior pulmonary vein during thoracoscopic lung cancer surgery.

Background: The intricate anatomical variations in lung structure often perplex thoracic surgeons, and the accurate identification of these variations is closely associated with favorable surgical outcomes.

Case Presentation: A 53-year-old female patient who underwent computed tomography (CT) examination due to chest discomfort, revealing the presence of a partial solid nodule highly suspected of early-stage lung cancer, measuring approximately 2.8 × 2.

Targeting mA demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels.

Chronic diabetic wounds are a prevalent and severe complication of diabetes, contributing to higher rates of limb amputations and mortality. N6-methyladenosine (mA) is a common RNA modification that has been shown to regulate tissue repair and regeneration. However, whether targeting mA could effectively improve chronic diabetic wound healing remains largely unknown.

Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations.

Background: High myopia (HM), characterized by a severe myopic refractive error, stands as a leading cause of visual impairment and blindness globally. HM is a multifactorial ocular disease that presents high genetic heterogeneity. Employing a genetic risk score (GRS) is useful for capturing genetic susceptibility to HM.

Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products.

Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs.

Effect of electroacupuncture versus sham electroacupuncture on postoperative ileus after laparoscopic surgery for left-sided colorectal cancer: study protocol for a multicentre, randomised, sham-controlled trial.

Introduction: Postoperative ileus (POI) is an inevitable complication after abdominal surgery, often hindering recovery and prolonging hospital stay. Despite the increasing use of electroacupuncture (EA) as an alternative treatment for gastrointestinal dysfunction, its effectiveness for POI is still controversial. This study aims to verify the efficacy and safety of EA in alleviating POI.

Biocompatibility of light responsive materials prepared for accommodative intraocular lenses manufacturing.

Aim: To investigate the biocompatibility and bacterial adhesion properties of light responsive materials (LRM) and analyze the feasibility and biosafety of employing LRM in the preparation of accommodative intraocular lenses (AIOLs).

Methods: Employing fundamental experimental research techniques, LRM with human lens epithelial cells (hLECs) and human retinal pigment epithelium cells (ARPE-19 cells) were co-cultured. Commercially available intraocular lenses (IOLs) were used as controls to perform cell counting kit-8 (CCK-8), cell staining under varying light intensities, cell adhesion and bacterial adhesion experiments.

Study on the Chemical Composition and Anti-Tumor Mechanisms of Fruit By-Products: Based on LC-MS, Network Pharmacology Analysis, and Protein Target Validation.

(Lour.) Skeels, commonly known as Wampee, are valued for their edible and medicinal qualities, yet their pericarp and seeds are often discarded, resulting in wasted resources. This study investigates the anti-tumor potential of these by-products, focusing on their chemical composition and underlying mechanisms of action.

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer.

This phase 2/3 trial (NCT04856787) assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 (a bevacizumab biosimilar) and XELOX (capecitabine plus oxaliplatin) as a first-line treatment for unresectable metastatic colorectal cancer (mCRC). In this phase 2 study, a total of 62 patients with untreated, histologically confirmed colorectal adenocarcinoma and no prior systemic therapy for metastatic disease were enrolled. Patients received SHR-1701 (30 mg/kg), bevacizumab (7.

Long-Term Function Recovery Following Upper Versus Lower Lobectomy for Lung Cancer: A Multicenter Longitudinal Cohort Study.

Background: The effects of lobectomy at various lung sites on postoperative function and recovery vary. This study aimed at assessing the long-term impact of upper versus lower lobectomy on patients' postoperative daily function by analyzing patient-reported outcomes.

Methods: This multicenter prospective cohort study enrolled patients from six hospitals in China.

Prediction of miRNA-disease association based on heterogeneous hypergraph convolution and heterogeneous graph multi-scale convolution.

Making the accurate prediction of miRNA-disease associations essential for medical interventions. Current computational models often fail to capture the complexity of miRNA-disease associations. This study proposes HHMDA, a method based on heterogeneous hypergraph convolution and heterogeneous graph multi-scale convolution, to predict the association between miRNA and disease.

Glutinous rice gel as all-natural ink supply for extrusion-based food 3D printing - the chemical basis of gel printability.

In this study, four varieties of glutinous rice were screened out of 18 varieties as representative model inks. Gel prepared using variety WN9612 of high amylose content displayed high viscosity and large overall print deviation (OPD = 17.4 ± 0.

Effects of fermented tea by Aspergillus cristatus on the characteristic aroma and non-volatile components of Jiang-flavor baijiu.

Background: Fu Brick tea (FBT) extract has been demonstrated to lower blood lipids, protect liver, and prevent obesity. Despite these benefits, there are no products on the market that combine FBT with other foods or beverages.

Result: In this study, we developed a novel product by combining FBT with high-alcohol Jiang-flavor baijiu, resulting in FBT-baijiu.

Boosting the Sustained Release Performance of Metronidazole and Ornidazole with MIL-53(Fe) Derived Spherical Porous Carbon.

Metal-organic framework (MOF) derived spherical porous carbon (SPC) has potential application value in the field of adsorption and sustained release of nitroimidazole drugs. This work used MIL-53(Fe) as a precursor and prepared spherical 3-aminophenol-formaldehyde resin containing MIL-53(Fe) crystals using the advanced Stöber method, followed by the successful preparation of MIL-53(Fe) derived SPC (MSPC) with a structure containing both micropores and mesopores through high-temperature carbonization. The effects of the doping amount of MIL-53(Fe) on the sphericity and particle size of MSPC were investigated.

AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.

Functional connectivity of the brain, characterized by interconnected neural circuits across functional networks, is a cutting-edge feature in neuroimaging. It has the potential to mediate the effect of genetic variants on behavioral outcomes or diseases. Existing mediation analysis methods can evaluate the impact of genetics and brain structurefunction on cognitive behavior or disorders, but they tend to be limited to single genetic variants or univariate mediators, without considering cumulative genetic effects and the complex matrix and group and network structures of functional connectivity.