Publications by authors named "Dai Lian"
Background: To investigate the cost-effectiveness of toripalimab plus chemotherapy versus chemotherapy alone for advanced non-small cell lung cancer (NSCLC) patients from a societal perspective.
Methods: A partitioned-survival model estimated the costs and cost-effectiveness of toripalimab plus chemotherapy versus standard chemotherapy for advanced NSCLC over 20 years. Clinical data were derived from the CHOICE-01 trial, and cost and utility inputs were gathered from Yaozh.
Cost-effectiveness of first-line systemic therapies for unresectable hepatocellular carcinoma.
Br J Clin Pharmacol
December 2024
Aims: To examine the cost-effectiveness of first-line systemic therapies recommended by the National Comprehensive Cancer Network guidelines for Unresectable Hepatocellular Carcinoma (uHCC) from the US social and payer's perspective.
Methods: A cost-effectiveness analysis was conducted using a three-state partitioned survival model to assess the cost-effectiveness of atezolizumab plus bevacizumab, tremelimumab plus durvalumab, durvalumab, lenvatinib and sorafenib as first-line treatments for uHCC. Clinical efficacy was derived from a published network meta-analysis.
Article Synopsis
- The approval of toripalimab, combined with chemotherapy, marks a significant advancement as the first FDA-approved treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC), but its cost-effectiveness remains underexplored in the U.S. context.
- A study using a partitioned survival model compared the cost-effectiveness of toripalimab plus chemotherapy against chemotherapy alone, finding that the toripalimab regimen provided higher quality-adjusted life years (QALYs) at a greater cost, resulting in an incremental cost-effectiveness ratio (ICER) of $74,004/QALY.
- The findings indicate that toripalimab is likely cost-effective, especially considering it has an 87.10%
Background: To explore the risk factors for hypoglycemia in patients with type 2 diabetes mellitus (T2DM) after intensive insulin therapy and the blood glucose monitoring strategy.
Methods: A total of 172 T2DM patients diagnosed from March 2019 to March 2021 were randomly divided into training (n=115) and test sets (n=57), and given intensive insulin therapy. After treatment, the training set was divided into hypoglycemia (n=35) and non-hypoglycemia groups (n=80).
Article Synopsis
- The study focuses on using adenosine deaminases acting on RNA (ADAR) for precise editing of RNA, addressing concerns about its effectiveness for therapy due to variable ADAR expression in tissues and species.
- Researchers found that delivering circular ADAR-recruiting RNAs (arRNAs) using AAV (adeno-associated virus) led to around 80% editing efficiency in non-human primates without any noticeable toxicity over a 4 to 13-week period.
- The successful correction of a genetic defect in a mouse model of Hurler syndrome suggests that AAV-delivered circular arRNAs could be a promising approach for therapeutic applications in humans.
Article Synopsis
- * A study with 1056 participants found that individuals with the rs6573816 GC genotype had a lower risk of glioma and that this variant affects disease progression, especially in men with high-grade gliomas.
- * The rs6573816 C allele was shown to reduce enhancer activity by altering the binding of the transcription factor POU2F1, which, in turn, lowers RAD51B expression and affects glioma susceptibility and progression.
Background: This study seeks to assess the quality of HEEs reporting on screening programs over the last 20 years in China, to identify potential predictors of reporting quality.
Methods: We performed a literature search of HEE studies published in PubMed, Embase, CNKI, and WANFANG from 2000 to 2021. The search terms included 'screening,' 'China,' 'CEA,' 'CBA,' 'CUA,' and all other names for health economic evaluation.
Dendrobium mixture (DM) is a patent Chinese herbal formulation consisting of Dendrobii Caulis, Astragali Radix, Rehmanniae Radix as the main ingredients. DM has been shown to alleviate diabetic related symptoms attributed to its anti-hyperglycaemic and anti-inflammatory activities. However, the effect on diabetic induced cognitive dysfunction has not been investigated.
View Article and Find Full Text PDFBackground: O-methylguanine-DNA methyltransferase (MGMT) is a pivotal enzyme for repairing DNA alkylation damage. Epigenetic modification of MGMT has been well known as a promising prognostic biomarker for glioma. However, the significance of genetic variations of MGMT in glioma carcinogenesis has not been fully elucidated.
View Article and Find Full Text PDFThe aim of this study was to investigate the correlations between serum calcium and clinical outcomes in patients with coronavirus disease 2019 (COVID-19). In this retrospective study, serum calcium levels, hormone levels and clinical laboratory parameters on admission were recorded. The clinical outcome variables were also recorded.
View Article and Find Full Text PDFGenetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant.
Cell Mol Neurobiol
May 2020
Article Synopsis
- * A study evaluated 400 glioma patients and 651 controls, revealing that the enhancer variant rs473426 significantly increases glioma risk, while another variant, rs1339499, was near significance.
- * Functional tests showed that the rs473426 variant lowers MAPKAP1 expression by reducing the binding of a transcription activator, supporting the idea that MAPKAP1 acts as a cancer suppressor in glioma development.
Purpose: O-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in repairing damaged DNA caused by alkylating agents. A number of cancer susceptibility loci have been recognized as enhancer variants. This study aimed to explore the significance of enhancer variants of in glioma susceptibility.
View Article and Find Full Text PDFMechanistic target of rapamycin () encodes a key modulator of cell growth, proliferation, and apoptosis. Previous studies have demonstrated that the dysregulation of is involved in the development and progression of several types of cancer, including glioma. In the present study, a comprehensive analysis was conducted to examine whether the expression quantitative trait loci (eQTLs) of are associated with the progression of glioma.
View Article and Find Full Text PDFExpression quantitative trait loci (eQTLs) have been recognized to be more likely to associate with complex diseases including cancer. As an essential scaffold for MTOR complex 1, RPTOR is necessary for the MTOR-catalyzed phosphorylation. This study examined the associations between the eQTLs of RPTOR and glioma susceptibility.
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