Publications by authors named "Dai Jingying"

Hypochlorous acid (HClO) is released by immune cells in the immune system, and it helps the body fight off infections and inflammation by killing bacteria, viruses, and other pathogens. However, tissue damage or apoptosis may also be induced by excess HClO. On this basis, we designed the probe TPE-NS by choosing tetraphenylethylene (TPE) as the luminescent unit and dimethylthiocarbamoyl chloride as the recognition site.

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Hematological malignancies originate from the hematopoietic system, including lymphoma, multiple myeloma, leukaemia, etc. They are highly malignant with a high incidence, a poor prognosis and a high mortality. Although the novel therapeutic strategies have partly improved the clinical efficacy of hematological malignancies, patients still face up with drug resistance, refractory disease and disease relapse.

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Exosomes, a kind of nano-vesicles released by various cell types, carry a variety of "cargos" including proteins, RNAs, DNAs and lipids. There is substantial evidence that exosomes are involved in intercellular communication by exchanging "cargos" among cells and play important roles in cancer development. Because of the different expressions of "cargos" carried by exosomes in biological fluids under physiological and pathological conditions, exosomes have the potential as a minimally invasive method of liquid biopsy for cancer diagnosis and prognosis.

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Leonurine is a bioactive alkaloid compound extracted from Leonurus japonicus Houtt, which potentially has immunomodulatory effects. The immunomodulatory effect and mechanism of leonurine on monocyte derived dendritic cells (moDCs) from healthy donors (HDs) and multiple myeloma (MM) patients were investigated for the first time. Peripheral blood from HDs and MM patients was isolated for peripheral blood mononuclear cells (PBMCs).

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To explore the effect of pomalidomide on the maturation of monocyte-derived dendritic cells (moDCs) from healthy donors (HDs) and multiple myeloma (MM) patients. MoDCs were generated by the incubation of monocytes from peripheral blood mononuclear cells (PBMCs) for 7 days in a medium consisting of 800 U/ml granulocyte-macrophage colony stimulating factor (GM-CSF), 500 U/ml interleukin-4 (IL-4), RPMI 1,640 medium, 5% human serum, 100 U/ml penicillin and 0.1 mg/ml streptomycin.

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Although cancer vaccines such as dendritic cell (DC) vaccines and peptide vaccines have become appealing and attractive anticancer immunotherapy options in recent decades, some obstacles have hindered their successful application in the clinical setting. The difficulties associated with the high cost of DC preparation, storage of DC vaccines, tumor-mediated immunosuppressive environment, identification of specific tumor antigens, and high degradation of antigen peptides in vivo limit the clinical application and affect the outcomes of these cancer vaccines. Recently, nanocarriers have been considered as a new approach for vaccine delivery.

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Article Synopsis
  • This study examines how dasatinib affects the maturation of dendritic cells derived from blood samples of healthy donors and chronic myelogenous leukemia (CML) patients.
  • The researchers cultured these cells with or without dasatinib and measured the expression of maturation-related markers over 10 days.
  • Results showed that dasatinib significantly enhanced certain cell surface markers associated with maturation in both healthy donors and CML patients, suggesting its potential use in dendritic cell-based immunotherapy.
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  • A study tested a new epigenetic treatment combining chidamide, decitabine, and thymalfasin on 24 acute myeloid leukemia patients post-stem cell transplant from April 2015 to May 2018.* -
  • The treatment was generally safe, with the main side effect being reversible grade 2 thrombocytopenia in 20 of the 24 patients, and all participants showed a positive response to the therapy, leading to decreased residual disease.* -
  • The overall and relapse-free survival rates were both 79.2%, and the treatment notably altered immune cell ratios, suggesting that monitoring Th1/Th17 ratios could help evaluate the treatment’s effectiveness and patient prognosis.*
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  • Multiple myeloma (MM) is an incurable cancer influenced by the bone marrow microenvironment, where exosomes play a pivotal role in supporting tumor growth and treatment failure.
  • Exosomes are nanoscale vesicles that can enhance the survival and spread of MM cells by interacting with other cells in the bone marrow, presenting a potential target for new therapies.
  • Research indicates that modifying exosomes for drug delivery and utilizing their unique properties might improve MM treatment outcomes and aid in diagnosis and prognosis.
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Purpose: The aim of this study was to explore the use of self-assembling nanoparticles loaded with two chemotherapy drugs for the treatment of multiple myeloma.

Materials And Methods: Nanoparticle systems were developed based on amine polyethylene glycol-polycaprolactone (NH2-PEG-PCL) to encapsulate 5-Aza-2'-deoxycytidine and Bortezomib using the self-assemble method. Morphological changes were observed by transmission electron microscopy (TEM), and the size, drug release, long-term stability, and release of reactive oxygen species (ROS) were analyzed.

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Vaccine is one of the most effective strategies for preventing and controlling infectious diseases and some noninfectious diseases, especially cancers. Adjuvants and carriers have been appropriately added to the vaccine formulation to improve the immunogenicity of the antigen and induce long-lasting immunity. However, there is an urgent need to develop new all-purpose adjuvants because some adjuvants approved for human use have limited functionality.

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Objective: To investigate the immunomodulatory effects of the tyrosine kinase inhibitor (TKI) dasatinib on T-cell subtypes in patients with chronic myeloid leukemia (CML).

Methods: T helper (Th) 1, Th2, regulatory T (Treg), and CD8T cell levels were detected in patients with CML (n = 9) before and after dasatinib treatment. The corresponding response level at the time of a blood test was evaluated.

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Multiple myeloma (MM) is an incurable hematological malignancy characterized by abnormal infiltration of plasma cells in the bone marrow. MicroRNAs (miRNAs) have emerged as crucial regulators in human tumorigenesis and tumor progression. miR-27, a novel cancer-related miRNA, has been confirmed to be implicated in multiple types of human tumors; however, its biological role in MM remains largely unknown.

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Monoclonal antibody (mAb), cytotoxins, and linker technology are three essential elements for developing a successful antibody-drug conjugate (ADC). In the research and development of ADCs industry, selected cytotoxins, such as auristatins and maytansines, are commonly tubulin inhibitors which are widely put into clinical use. Thereafter, with the booming development of ADCs, a large number of pharmaceutical companies have expanded a wide range of selectable cytotoxin product lines as well.

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Article Synopsis
  • The study aimed to compare the immunomodulatory effects of three tyrosine kinase inhibitors (TKIs)—dasatinib, nilotinib, and imatinib—on patients with chronic myeloid leukemia (CML).
  • Researchers assessed T cell subtypes in CML patients treated with these TKIs for over three months and examined correlations with clinical outcomes.
  • Results indicated that a significantly higher percentage of dasatinib patients had elevated Th1 levels compared to those on nilotinib and imatinib, and patients with normal or high Th1 proportions showed better treatment responses.
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Although lenalidomide and pomalidomide are well-established treatment options in patients with multiple myeloma, their immune-modulating effects are not fully understood. While CD8CD28 regulatory T-cells in patients with hematologic disorders display a known immune-escape mechanism, we show that lenalidomide can overcome the immunosuppressive impact of CD8CD28 T-cells. We analyzed the antigen-specific T-cell responses of healthy donors and patients with multiple myeloma with or without the addition of autologous CD8CD28 T-cells in the absence and presence of lenalidomide.

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Both tetrandrine (Tet) and 5-bromotetrandrine (BrTet) can effectively reverse P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). The structure of multidrug resistance associated protein 7 (MRP7) has its own specificity and difference compared with other members of the MRP family. This study was aimed to investigate whether Tet and BrTet can inhibit the expression level of MRP7 so as to further look into the mechanisms of the reversal effects of Tet and BrTet on MDR.

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