Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor.

Pterygium is an ocular disease in which the conjunctival tissue invades the cornea. When the pterygium tissue reaches the pupillary region, the visual function of the patient is affected. Currently, surgical removal is the only effective treatment.

GLP-1 and IL-6 regulates obesity in the gut and brain.

Obesity is a chronic metabolic disease characterized by excessive nutrient intake leading to increased subcutaneous or visceral fat, resulting in pathological and physiological changes. The incidence rate of obesity, an important form of metabolic syndrome, is increasing worldwide. Excess appetite is a key pathogenesis of obesity, and the inflammatory response induced by obesity has received increasing attention.

Accumulation of lipophilic and proteinophilic halogenated organic pollutants (HOPs) in the different types of feathers of laying hens.

This study investigated the bioaccumulation of halogenated organic pollutants (HOPs) in three types of feathers from laying hens through exposure experiments. The HOPs included lipophilic polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), as well as proteinophilic perfluoroalkyl carboxylic acids (PFCAs). Concentrations of PCBs, PBDEs, and short-chain PFCAs (≤8) were significantly higher in the body feathers than in the primary feathers, while long-chain PFCAs (>8) showed no significant differences among primary, tail, and body feathers.

Optimization of Cholesterol-Loaded Cyclodextrin Combined with Soybean Lecithin as a Cryoprotectant for Rooster Sperm.

There are many applications of soybean lecithin (SL) and cholesterol-loaded cyclodextrin (CLC) in sperm freezing processes. To the best of our knowledge, there have been few cases of the combined use of SL and CLC in freezing rooster semen. We investigated the effects of CLC, SL, and their combination on rooster sperm cryodamage.

Comprehensive assessment of risk factors and development of novel predictive tools for perioperative hidden blood loss in intertrochanteric femoral fractures: a multivariate retrospective analysis.

Objectives: To identify independent risk factors for perioperative hidden blood loss (HBL) in intertrochanteric femoral fractures (ITFs) and to develop a predictive model.

Methods: We enrolled 231 patients with ITFs who underwent proximal femoral nail antirotation (PFNA) surgery at the Orthopedics Department of Northern Jiangsu People's Hospital, Jiangsu Province, China, from January 2021 to December 2023. Hidden blood loss was calculated using the OSTEO formula, and independent risk factors were screened using the Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression.

[GSK484, a PAD4 inhibitor, improves endothelial dysfunction in mice with sepsis-induced lung injury by inhibiting H3Cit expression].

Objectives: To investigate the inhibitory effect of GSK484, a PAD4 inhibitor, on H3Cit expression following sepsis and its effects for improving sepsis-induced endothelial dysfunction.

Methods: Eighteen C57BL/6 mice were randomized into sham-operated group, sepsis model group and GSK484 treatment group (6), and in the latter two groups, models of sepsis were established by cecal ligation and puncture (CLP). The mice in GSK484 treatment group were given an intraperitoneal injection of GSK484 (4 mg/kg) on the second day following the surgery.

Predicting craniofacial fibrous dysplasia growth status: an exploratory study of a hybrid radiomics and deep learning model based on computed tomography images.

Objective: This study aimed to develop 3 models based on computed tomography (CT) images of patients with craniofacial fibrous dysplasia (CFD): a radiomics model (Model Rad), a deep learning (DL) model (Model DL), and a hybrid radiomics and DL model (Model Rad+DL), and evaluate the ability of these models to distinguish between adolescents with active lesion progression and adults with stable lesion progression.

Methods: We retrospectively analyzed preoperative CT scans from 148 CFD patients treated at Shanghai Ninth People's Hospital. The images were processed using 3D-Slicer software to segment and extract regions of interest for radiomics and DL analysis.

Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.

Curcumin is a hydrophobic polyphenolic compound with potent anti-inflammatory properties. However, whether it can achieve therapeutic effects by alleviating neuroinflammation in patients with Parkinson's disease (PD) and its potential mechanism are still unknown. This study explored the effects of curcumin on neuroinflammation in dopaminergic neurons and deciphered its direct target in the histone deacetylase 6 (HDAC6)-Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) pathway, revealing the potential role of curcumin in the treatment of Parkinson's disease.

phage ΦPNJ-9 adheres to mucus via a variant Hoc protein.

Phages, as antagonists of bacteria, hold significant promise for combating drug-resistant bacterial infections. Their host specificity allows phages to target pathogenic bacteria without disrupting the gut microbiota, offering distinct advantages in the prevention and control of intestinal pathogens. The interaction between the phage and the gut plays a crucial role in the efficacy of phage-mediated bacterial killing.

The carbon transport mediated by the mild oxygen minimum zone (OMZ) in the seamount area of the Western Pacific.

This study analyzed the relationship between the oxygen minimum zone (OMZ) and various types of carbon, such as POC, DOC, and DIC, in the Y3 seamount area in the Western Pacific. The results indicated that the OMZ was located at 200-1000 m and a threshold of 100 μmol/kg was established for this area of the Western Pacific. The DOC and POC changed drastically out of OMZ while they were relatively stable within the OMZ due to the low oxygen.

Application of extended immunotherapy in advanced clear cell renal cell carcinoma treated with first-line combination of immune-checkpoint inhibitor and tyrosine kinase inhibitor.

Purpose: To evaluate the efficacy and safety of extended immunotherapy in first-line immune checkpoint inhibitors (ICIs)-tyrosine kinase inhibitors (TKIs) combination treatment for advanced renal cell carcinoma (RCC).

Patients And Methods: We retrospectively analyzed data from patients with advanced RCC who received first-line ICIs-TKIs combination treatment at West China Hospital of Sichuan University between October 2018 and July 2024. Patients who are assessed as having a disease control status after 2 years of continuous treatment will continue to receive immune checkpoint inhibitors until the inhibitors are discontinued due to disease progression or death.

Lignin nanoparticle/MXene-based conductive hydrogel with mechanical robustness and strain-sensitivity property via rapid self-gelation process towards flexible sensor.

Conductive hydrogels have been showcased with substantial potential for soft wearable devices. However, the tedious preparation process and poor trade-off among overall properties, i.e.

Engineering the Self-Assembly Pathways of POSS-Peptide Amphiphiles to Form Diverse Cross-β Structures.

Cross-β structures are crucial in driving protein folding and aggregation. However, due to their strong aggregating tendency, the precise control of the self-assembly of β-sheet-forming peptides remains a challenge. We propose a molecular geometry strategy to study and control the self-assembly of cross-β structures.

Structural Regulating of Cu-based Metallic Electrocatalysts for CO2 to C2+ Products Conversion.

Electrochemical carbon dioxide reduction reaction (CO2RR) to highly value-added C2+ fuels or chemicals is a promising pathway to address environment issues and energy crisis. In the periodic table, Cu as only the candidate can convert CO2 to C2+ products such as C2H4 and C2H5OH due to the suitable absorption energy to reaction intermediate. Application of Cu is limited for its low activity and poor selectivity.

Cross-technique transfer learning for autoplanning in magnetic resonance imaging-guided adaptive radiotherapy for rectal cancer.

Purpose: Automated treatment plan generation is essential for magnetic resonance imaging (MRI)-guided adaptive radiotherapy (MRIgART) to ensure standardized treatment-plan quality. We proposed a novel cross-technique transfer learning (CTTL)-based strategy for online MRIgART autoplanning.

Method: We retrospectively analyzed the data from 210 rectal cancer patients.

PpNAP4 and ethylene act in a regulatory loop to modulate peach fruit ripening and softening.

Ripening significantly influences fruit quality and commercial value. Peaches (Prunus persica), a climacteric fruit, exhibit increased ethylene biosynthesis and decreased fruit firmness during ripening. NAC-like proteins activated by AP3/P1 (NAP) proteins are a subfamily of NAC transcription factors, and certain NAPs have been shown to intervene in fruit ripening.

Accelerated arsenic decontamination using graphene oxide-supported metal-organic framework nanoconfined membrane for sustainable performance.

Developing highly efficient bimetallic metal-organic frameworks (MOFs) as catalysts for Fenton-like reactions holds significant promise for decontamination processes. Although MOFs with excellent decontamination capabilities are achievable, ensuring their long-term stability, especially in the organoarsenic harmless treatment, remains a formidable challenge. Herein, we proposed a unique nanoconfinement strategy using graphene oxide (GO)-supported Prussian blue analogs (PBA) as catalytic membrane, which modulated the peroxymonosulfate (PMS) activation in p-arsanilic acid (p-ASA) degradation from traditional radical pathways to a synergy of both radical and non-radical pathways.

Biogenic synthesis of N-doped carbon dots from S. cumini seeds for prostate cancer biomarker citrate detection, its live cancer cell imaging.

Citrate is a potential biomarker for early stage detection of prostate cancer (PC), its concentration significantly dropped to 2-20 mM in PC patients. Herein, a cheap, simple, and reliable citrate sensor was proposed based on the biogenic synthesis of nitrogen-doped carbon dots (N-CDs) derived from the biowaste of Syzygiumcumini (S. cumini) seeds.

Prx5 overexpression protect against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and inflammation via the TLR4/NF-κB pathway.

Background: The clinical application of Doxorubicin (DOX) is constrained due to its cardiotoxic side effects. Oxidative stress and inflammation are crucial mechanisms driving doxorubicin-induced cardiotoxicity (DIC). Peroxiredoxin 5 (Prx5) is central to these inflammatory responses.

Revolutionizing cross-border e-commerce: A deep dive into AI and big data-driven innovations for the straw hat industry.

This paper investigates the impact of artificial intelligence (AI) and big data analytics on optimizing cross-border e-commerce efficiency for straw hat manufacturers in Zhejiang Province, China. It identifies market and consumer demand trends through machine learning analysis of comprehensive e-commerce data and leverages generative AI to revolutionize production and marketing processes. The integration of AI-generated content (AIGC) technology facilitates streamlined design-to-production cycles and rapid adaptation to market changes and consumer feedback.

Enrichment mechanism and probabilistic health risk assessment of high-fluoride groundwater in Gaomi City, China.

Fluoride (F) is the most important inorganic pollutant in groundwater that affects human health, and analyzing the causes of high-fluoride groundwater is a prerequisite for protecting the health of residents. To comprehensively understand the enrichment characteristics of groundwater in the high-fluoride areas, this study systematically investigated the concentrations of fluoride in Gaomi City, a typical study area in the Jiaolai Plain and explored the spatiotemporal distribution patterns, enrichment mechanisms, and the probabilistic health risk associated with F. The results indicate that there is serious fluorine pollution in groundwater, which is mainly concentrated in the alluvial plain in the north and affected by topographical and aquifer characteristics.