Publications by authors named "Dahye Moon"
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterized by persistent inflammation in the airways, resulting in narrowing and obstruction of the air passages. The development of COPD is primarily attributed to long-term exposure to irritants, such as cigarette smoke and environmental pollutants. Among individuals hospitalized for exacerbations of COPD, approximately one in five is readmitted within 30 days of discharge or encounters immediate post-discharge complications, highlighting a lack of adequate preparedness for self-management.
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- - Oncolytic viruses, like herpes simplex virus (HSV), are promising for cancer treatment because they can specifically target and destroy cancer cells without harming normal cells and have a good safety record.
- - Researchers developed a new oncolytic HSV-1 (∆6/GM/IL12) that co-expresses interleukin-12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF), which showed enhanced tumor control and improved survival in a mouse model of melanoma compared to other treatments.
- - The combination of IL-12 and GM-CSF from the engineered HSV led to increased activation of immune cells (like CD4 and CD8 T cells) and a stronger immune response