Publications by authors named "Dahwan Lim"

The activation or inactivation of B-cell lymphoma-2 (Bcl-2) antagonist/killer (Bak) is critical for controlling mitochondrial outer membrane permeabilization-dependent apoptosis. Its pro-apoptotic activity is controlled by intermolecular interactions with the Bcl-2 homology 3 (BH3) domain, which is accommodated in the hydrophobic pocket of Bak. Bcl-2-interacting protein 5 (Bnip5) is a noncanonical BH3 domain-containing protein that interacts with Bak.

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Article Synopsis
  • Bak is a key player in apoptosis, part of the Bcl-2 family, and activates through binding with specific proapoptotic proteins.
  • The study focused on how Pxt1, a protein found only in the testis, interacts with Bak, leading to Bak's activation and promoting cell death.
  • By determining the crystal structure of the Bak-Pxt1 complex, researchers discovered that Pxt1 is a novel activator of Bak, enhancing our understanding of apoptosis signaling pathways.
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Influenza virus is one of the most challenging viruses threating human health. Since infection with influenza virus triggers inflammatory responses and induces cell death, the molecular and cellular mechanisms by which the virus-infected cells undergo apoptotic and necrotic cell death have been widely studied. However, most of the studies have focused on the molecular events occurring in the cytosol and there is limited information on the physiological correlation between virus-induced cell death and the viral pathogenesis in vivo.

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Article Synopsis
  • Antiapoptotic Bcl-2 proteins prevent cell death by interacting with proteins that promote apoptosis and feature a specific binding area for them.
  • Human Pxt1, a protein involved in male germ cell development, has a BH3 domain that binds to Bcl-2 proteins, and it is longer than its mouse counterpart, which affects its binding capabilities.
  • The study revealed that the human Pxt1 BH3 domain has conserved residues essential for binding to the Bcl-xL protein and highlighted that this binding behavior differs significantly from mouse Pxt1, potentially influencing how apoptosis is regulated in different species.
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Zaire ebolavirus, commonly called Ebola virus (EBOV), is an RNA virus that causes severe hemorrhagic fever with high mortality. Viral protein 35 (VP35) is a virulence factor encoded in the EBOV genome. VP35 inhibits host innate immune responses and functions as a critical cofactor for viral RNA replication.

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Autophagy is an important process for protein recycling. Oligomerization of p62/SQSTM1 is an essential step in this process and is achieved in two steps. Phox and Bem1p (PB1) domains can oligomerize through both basic and acidic surfaces in each molecule.

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