Addressing Social Determinants of Health in a Free Clinic Setting: A Student-Run Free Clinic and Community Resource Navigator Program.

Background: Social determinants of health (SDOH) disproportionately affect medically-underserved populations such as those cared for in student-run free clinics (SRFCs). Community resource programs which address SDOH play an important role in reducing health disparities. The Southside MEDiC Clinic (SMC), a SRFC at the University of Wisconsin School of Medicine and Public Health, partnered with the Community Resource Navigator Program (CRNP), a community resource program focused on addressing SDOH, to remove barriers that prevent positive health outcomes for SMC patients.

Neutrophil-to-eosinophil ratio as a biomarker for clinical outcomes in advanced stage melanoma patients treated with anti-PD-1 therapy.

Neutrophil-to-lymphocyte ratios (NLR) and eosinophil counts are associated with improved survival in melanoma patients treated with immune checkpoint inhibitors, but no study has investigated neutrophil-to-eosinophil ratios (NER) as a predictive indicator in this population. In this retrospective study evaluating anti-PD-1 treated patients with advanced melanoma, progression-free survival (PFS), overall survival (OS), objective response rates (ORR), and risk of high-grade (grade ≥3) immune-related adverse events (irAEs) were compared between groups defined by median pretreatment NLR and NER as well as median NLR and NER at 1-month post-treatment. Lower baseline NLR and NER were associated with improved OS [HR: 0.

Comparison of urine fibrinogen and interleukin-6 concentrations between healthy dogs and dogs with risk factors for enterococcal bacteriuria.

Objective: To compare urine concentrations of fibrinogen (uFIB) and interleukin-6 (uIL-6) between dogs with risk factors for enterococcal bacteriuria and healthy dogs.

Sample: Banked urine samples with negative aerobic culture results from 8 dogs with urolithiasis, 9 dogs with anatomic abnormalities of the lower portion of the urinary tract (LUT), 10 dogs with LUT neoplasia, and 21 healthy control dogs.

Procedures: Urine creatinine concentration (uCrea) was determined by an automated biochemical analyzer, and uFIB and uIL-6 were determined by dog-specific ELISAs.

Risk factors for enterococcal bacteriuria in dogs: A retrospective study.

Background: In humans, Enterococcus spp. urinary tract infections (UTI) are commonly associated with urinary catheter-induced urothelial inflammation but this is not the case in dogs.

Hypothesis/objectives: To identify risk factors predisposing dogs to enterococcal bacteriuria.

Comparison of commercial manual extraction kits for RNA isolation from canine whole blood.

High quantities of quality RNA are necessary for many veterinary laboratory tests. Several commercial kits are available for RNA isolation from human whole blood; their resultant RNA yield and purity have not been reported for canine whole blood, to our knowledge. We assessed the performance of 4 RNA extraction kits (RiboPure, TRIzol, RNeasy Protect animal blood, and QIAamp RNA blood mini).