Depth profiling of epidermal hydration inducing improvement of skin roughness and elasticity: in vivo study by confocal Raman spectroscopy.

Introduction: Skin hydration in the stratum corneum plays an important role in skin condition, and skin efficacy properties are influenced by its hydration level. However, few studies have identified the correlation between changes in skin hydration content and skin characteristics by skin depth level.

Aims: This study aims to determine how changes in skin hydration at specific depth levels affect skin condition by long-term tracking changes in hydration of stratum corneum and viable epidermis after usage of moisturizer.

Novel C6-substituted 1,3,4-oxadiazinones as potential anti-cancer agents.

The insulin-like growth factor 1 receptor (IGF-1R) is a membrane receptor tyrosine kinase over-expressed in a number of tumors. However, combating resistance is one of the main challenges in the currently available IGF-1R inhibitor-based cancer therapies. Increased Src activation has been reported to confer resistance to anti-IGF-1R therapeutics in various tumor cells.

When Indolizine Meets Quinoline: Diversity-Oriented Synthesis of New Polyheterocycles and Their Optical Properties.

Fluorescence-based technologies play a pivotal role in various biomedical applications. Here we report an efficient route to a new class of fluorophores, indolizino[3,2-c]quinolines, via the oxidative Pictet-Spengler cyclization strategy. The condensation of several 2-methylpyridines with 2-bromo-2'-nitroacetophenone allowed for the rapid assembly of indolizines with a 2-nitrophenyl group at the C2 position.

Lumazine peptides from the marine-derived fungus Aspergillus terreus.

Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells.