Identifying the needs of natural caregivers caring for a person with dementia: a mixed method study.

Background: Many available interventions to reduce challenges of natural caregivers of people living with dementia have limited efficacy since they do not meet the caregiver's individual needs. This study aims to evaluate caregivers' needs with the future goal of developing a tailored, multicomponent intervention to ease caregiver challenges through appropriate caregiver-centred interventions.

Methods: Mixed method study using a convergent design with quantitative and qualitative data collection and analysis performed at similar times.

MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study.

There is unmet need for non-invasive immunomonitoring to improve diagnosis and treatment of acute rejection in vascularized composite allotransplantation (VCA). Circulating matrix metalloproteinase 3 (MMP3) was described as a candidate non-invasive biomarker to predict treatment response to acute rejection in clinical VCA. However, larger validation studies are yet to be reported to allow for more definitive conclusions.

Influence of allograft weight to recipient bodyweight ratio on outcome of cadaveric renal transplantation.

Aim: One of the factors that may affect survival and function of kidney graft is its functional mass.

Methods: In a prospective study, we investigated the impact of the ratio between donor kidney weight in grams and recipient bodyweight in kilograms (DKW/RBW) on creatinine clearance, inulin clearance, and proteinuria: 154 kidneys from deceased donors were weighed and the mean kidney weight was 227 ± 59 g, the bodyweight of the recipients was 64 ± 19 kg.

Results: This study showed significant lower values of modification of diet in renal disease (MDRD) in patients with DKW/RBW ratio 2.