Severe Acute Bacterial Infections in Children With Sickle Cell Disease in Togo.

Background: Bacterial infections are considered a major cause of morbidity and mortality in patients, especially children, with sickle cell disease.

Objectives: This study aims at determining, a year after the introduction of the 13-valent pneumococcal conjugate vaccine the distribution of severe acute bacterial infections and germs in children with sickle cell disease.

Patients And Methods: Records of children 0 to 15 years of age and admitted from January 1, 2015 to December 31, 2019 (5 y), were examined retrospectively in the four sickle cell monitoring units in Lomé.

Half of rifampicin-resistant Mycobacterium tuberculosis complex isolated from tuberculosis patients in Sub-Saharan Africa have concomitant resistance to pyrazinamide.

Background: Besides inclusion in 1st line regimens against tuberculosis (TB), pyrazinamide (PZA) is used in 2nd line anti-TB regimens, including in the short regimen for multidrug-resistant TB (MDR-TB) patients. Guidelines and expert opinions are contradictory about inclusion of PZA in case of resistance. Moreover, drug susceptibility testing (DST) for PZA is not often applied in routine testing, and the prevalence of resistance is unknown in several regions, including in most African countries.

Genetic characterization of HIV-1 strains in Togo reveals a high genetic complexity and genotypic drug-resistance mutations in ARV naive patients.

In this study, the genetic diversity of HIV-1 and the presence of genotypic drug-resistance mutations in ARV naive patients in Lomé, the capital city of Togo, was documented for the first time. Between June 2006 and January 2007, 83 plasma samples were collected in Lomé from HIV-1 positive and antiretroviral (ARV) naive individuals. Pol (protease+RT) and env (V3-V5) regions were amplified and sequenced.

[New Staphylococcus aureus strains].

Staphylococcus aureus strains are present in the nose of 30% of healthy humans and are responsible for skin and soft tissue infections. Deep seated infections secondarily occurred such as osteomyelitis or infective endocarditis. New toxin-associated clinical entities have been recognized such as the toxin shock syndrome, the staphylococcal scarlet fever, the staphylococcal scalded skin syndrome or the necrotising pneumonia.