Gap effect and express saccades generation in amblyopia.

Amblyopia is a neurodevelopmental vision disorder that is associated with abnormal visual stimulation during early childhood. Although our knowledge regarding spatial vision deficits in amblyopic subjects is well established, the neural control of eye movements in amblyopia is yet to be explored. In the present study we have evaluated the gap effect, and for the first time (to our best knowledge), express saccades generation in amblyopic (strabismic as well as anisometropic) and age-matched control subjects.

Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne.

Background: Acne vulgaris often affects the face, shoulders, chest, and back, but treatment of nonfacial acne has not been rigorously studied.

Objectives: Assess the safety and efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate facial and truncal acne.

Methods: Two phase III double-blind, randomized, vehicle-controlled, 12-week studies of once-daily trifarotene cream versus vehicle in subjects aged 9 years or older.

Not only amblyopic but also dominant eye in subjects with strabismus show increased saccadic latency.

Amblyopia is a developmental disorder of vision usually associated with the presence of strabismus and/or anisometropia during early childhood. Subject literature has shown that both the amblyopic and fellow eyes (especially in strabismic subjects) may manifest a variety of perceptual and oculomotor deficits. Previous studies using simple saccadic responses (pro-saccades) showed an increased saccadic latency only for the amblyopic eye viewing conditions.

The amblyopic eye in subjects with anisometropia show increased saccadic latency in the delayed saccade task.

The term amblyopia is used to describe reduced visual function in one eye (or both eyes, though not so often) which cannot be fully improved by refractive correction and explained by the organic cause observed during regular eye examination. Amblyopia is associated with abnormal visual experience (e.g.