Pharmacotherapy for spasticity.

Rehabilitation together wit pharmalogical therapy determines effiacy of pasticity treatment. In the article we present drugs that diminish muscle tension according to their way of administration: drugs injected to the muscle, e.g.

Changes of percentages in immune cells phenotypes and cytokines production during two-year IFN-beta-1a treatment in multiple sclerosis patients.

Objective: The aim of the study was to find out whether INF-beta-1a influences the immune profile of peripheral blood (PB) leukocytes in MS patients.

Method: We have studied 20 patients with relapsing-remitting form of MS treated with INF-beta-1a using twocolor cytometry. We determined immune cells phenotypes and production of some cytokines: IL-4, IL-10, IL-12, IFN-gamma, before drug administration and after starting the treatment.

[Axonal degeneration in the pathogenesis of multiple sclerosis].

Axonal degeneration plays an important role in the cumulation of disability in patients with multiple sclerosis (MS). Pathological studies have demonstrated axonal damage, particularly in area of acute inflammation and demyelination, and in chronic lesions. The mechanism of axonal loss is uncertain, but may involve axonal degeneration which is secondary to demyelination.