Diagnostic performance of S100B protein serum measurement in detecting intracranial injury in children with mild head trauma.

Objective: To assess the accuracy of S100B serum level to detect intracranial injury in children with mild traumatic brain injury.

Methods: A multicenter prospective cohort study was carried out in the paediatric emergency departments of three tertiary hospitals in Switzerland between January 2009 and December 2011. Participants included children aged <16 years with a mild traumatic brain injury (GCS ≥13) for whom a head CT was requested by the attending physician.