Publications by authors named "Dagmar Graf"
Article Synopsis
- - Patients with ataxia-telangiectasia (A-T) often experience severe issues, including progressive coordination problems, weakened immune response, and higher cancer risk, with those having IgA deficiency facing even worse outcomes.
- - A study of 659 A-T patients showed that those with IgA deficiency had significantly lower lymphocyte counts and altered immune cell types compared to those without IgA deficiency, indicating poorer health.
- - The findings suggest that IgA deficiency serves as a simple indicator of worse prognosis in A-T patients, emphasizing the need for careful monitoring and potential treatment strategies for those affected.
The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
View Article and Find Full Text PDFInterleukin-21 (IL-21) is an important promoter for differentiation of human B cells into immunoglobulin (Ig)-secreting cells. The objective of this study was to evaluate an IL-21-based approach to induce immunoglobulin production in B cells from patients with common variable immunodeficiency (CVID) or selective IgA deficiency (IgAD). We show that a combination of IL-21, IL-4, and anti-CD40 stimulation induces class-switch recombination to IgG and IgA and differentiation of Ig-secreting cells, consisting of both surface IgG(+) (sIgG(+)) and sIgA(+) B cells and CD138(+) plasma cells, in patients with CVID or IgAD.
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