Publications by authors named "Dagmar E Verel"

Influenza virosomes serve as antigen delivery vehicles and pre-existing immunity toward influenza improves the immune responses toward antigens. Here, vaccine efficacy was evaluated in non-human primates with a COVID-19 virosome-based vaccine containing a low dose of RBD protein (15 µg) and the adjuvant 3M-052 (1 µg), displayed together on virosomes. Vaccinated animals (n = 6) received two intramuscular administrations at week 0 and 4 and challenged with SARS-CoV-2 at week 8, together with unvaccinated control animals (n = 4).

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Article Synopsis
  • Atherosclerotic cardiovascular diseases (CVD) are major global health threats, with monocyte-derived macrophages playing a critical role in their development, particularly through a process called trained immunity, which is triggered by oxidized low-density lipoproteins (oxLDL).
  • The study investigates how oxLDL influences internal processes in monocytes, revealing that exposure leads to changes in steroid hormone levels, specifically a decrease in progesterone after LPS stimulation.
  • Notably, progesterone uniquely reduces inflammation (like TNFα and IL-6 production) associated with trained immunity, and genetic factors related to steroid hormone receptors correlate with trained immunity responses, suggesting that progesterone may help explain the lower CVD rates seen in premenopausal women
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