Publications by authors named "Dagmar Adamkova"
Hand and foot osteosarcoma represents ~1% of all diagnosed cases of osteosarcoma. The rarity of osteosarcoma of the hand and foot leads to frequent misdiagnosis, delayed diagnosis or incorrect treatments, which can lead to fatal consequences. Typically, salvaging the affected limb is the treatment of choice, and with the use of chemotherapy, 60-65% of patients with osteosarcoma can be treated without amputation.
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- Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that has an infiltrative growth pattern, making surgical removal challenging; limited data exists on its management and outcomes.
- A study analyzed data from 347 adult DFSP patients who underwent surgery across multiple institutions, finding that most presented with symptoms and that R0 resection (no cancerous cells at the margins) was achieved in 89.5% after multiple attempts.
- Results showed a 98.8% disease-specific survival rate with recurrence being relatively low, highlighting the effectiveness of surgery but indicating the need for careful margin assessment and techniques due to the tumor's aggressive nature.
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- Myxofibrosarcoma is a type of cancer that tends to grow infiltratively, making it hard to achieve clear surgical margins, which leads to a high chance of local recurrence.
- In a study of 111 patients, researchers found a 5-year overall survival rate of 65.5%, with age over 65, larger tumor size, and higher tumor grade negatively impacting this rate.
- While clear surgical margins positively affect recurrence-free survival, a margin of just 2 mm may not be enough, indicating that wider margins could be necessary to lower the risk of recurrence.
Giant cell tumour of bone (GCTB) is one of the most common local aggressive tumourous lesions with a wide variety of biological behaviour. However, there are no clear indicative criteria when choosing the type of procedure and the complication rates remain high, especially in terms of local recurrence. The purpose of the study was to (1) identify the main risk factors for local recurrence, (2) evaluate the recurrence-free survival in dependence on neoadjuvant denosumab use and the type of procedure, and (3) compare the functional outcomes after curettage and en bloc resection.
View Article and Find Full Text PDFBackground: At present, lung cancer ranks among the most frequent malignant diseases. However, according to literature data, mesenchymal lung tumors are very rare, representing less than 0.5% of all malignant lung tumours.
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