Publications by authors named "Dagang Zhu"
Background: Primary sclerosing cholangitis (PSC) is a complex disease with pathogenic mechanisms that remain to be elucidated. Previous observational studies with small sample sizes have reported associations between PSC, dyslipidemia, and gut microbiota dysbiosis. However, the causality of these associations is uncertain, and there has been no systematic analysis to date.
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- Chemoresistance in colorectal cancer (CRC) complicates treatment, and this study focuses on the role of MDM2, a ubiquitin E3 ligase, in influencing CRC cell growth and response to chemotherapy.
- Researchers analyzed the interaction between MDM2 and the transcription factor ING3, discovering that MDM2 reduces ING3 protein stability through a process called ubiquitination, which leads to increased cell proliferation and decreased apoptosis in CRC cells.
- The study also confirms, through experiments in mice, that the combined effects of MDM2 and reduced ING3 expression contribute to tumor growth and chemoresistance in colorectal cancer.