Publications by authors named "Dafne N Sanchez"
Article Synopsis
- The review aimed to analyze the use of frailty assessments in recent studies focused on older women (65+) with breast cancer, specifically looking at their impact on survival and mortality outcomes from 2017 to 2022.
- A systematic search of databases like MEDLINE, EMBASE, and Cochrane Library identified 130 relevant observational studies out of nearly 10,000 screened, but only 11 of these (8.5%) incorporated frailty assessments.
- The findings revealed significant variability in how frailty is defined and classified across studies, with key assessments like the Balducci score and Geriatric 8 tool being used, and quantified frailty classifications showing that 18% to 29% were considered pre
Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in are known, the essential genes in which mutations can cause increased GCR rates are not well understood. Here 2 GCR assays were used to screen a targeted collection of temperature-sensitive mutants to identify mutations that caused increased GCR rates.
View Article and Find Full Text PDFNeurons must maintain protein and mitochondrial quality control for optimal function, an energetically expensive process. The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that promote mitochondrial biogenesis and oxidative metabolism. We recently determined that transcriptional dysregulation of PPARδ contributes to Huntington's disease (HD), a progressive neurodegenerative disorder resulting from a CAG-polyglutamine repeat expansion in the huntingtin gene.
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