Publications by authors named "Daffini L"
Metastases to the sellar region and pituitary gland are rare and usually occur in advanced cancers, commonly breast and lung adenocarcinomas. Metastases from sarcomas to the pituitary gland are extremely rare. Here, we report the case of a 52-year-old man who had undergone surgery and radiotherapy for a clear cell sarcoma (CCS) of the knee at age of 42.
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- Thyroid storm is a serious condition due to extreme levels of thyroid hormone, and it can be triggered by various factors, including the long-term use of iodine-based homeopathic remedies.* -
- A case study involved a 55-year-old Italian woman with a history of Graves' disease who developed a thyroid storm and cardiac arrest after using homeopathic treatments, showing dangerously high iodine levels in her blood and urine.* -
- The excessive iodine intake from the homeopathic medicine not only led to a hyperthyroid crisis but also complicated treatment options, highlighting the risks of alternative therapies when managing thyroid conditions.*
We report a challenging autopsy case with an insidious clinical presentation with diffuse lepto- and pachymeningeal enhancement in a context of a complex clinical history. Clinical features, neuroradiological and anamnestic data were consistent with central nervous system (CNS) dissemination of a previously known lambda restricted multiple myeloma. Autoptic findings allowed to discard this hypothesis.
View Article and Find Full Text PDFBackground. Recently, it has been shown that liquid L-T4 formulation can be ingested with breakfast. This study looked to extend these findings by investigating whether a soft gel capsule formulation of L-T4 could also be ingested at breakfast time.
View Article and Find Full Text PDFBackground: Levothyroxine (LT4) is the recommended treatment for millions of hypothyroid patients. Current guidelines recommend that LT4 tablets be taken in a fasting state, but inability to adhere to this often leads to poor therapy compliance.
Methods: A randomized, double-blind, placebo-controlled, crossover trial was conducted in previously untreated hypothyroid patients randomly assigned to receive an oral solution of LT4 either at least 30 minutes before breakfast or directly at breakfast time.
Background: The majority of clinicians suggest that enteral feedings should be held 1-2 h prior to and after L-T4 administration despite lack of data for continuous enteral nutrition.
Aim: The aim of this study was to: (1) compare the thyroid hormonal profile in patients submitted to L-T4 treatment in tablets or liquid formulation with an enteral feeding tube; (2) evaluate the nursing compliance with the two different formulations.
Subjects And Methods: 20 euthyroid patients submitted to total laryngectomy and thyroidectomy consecutively started L-T4 treatment in tablets (Group T) or in liquid formulation (Group L) with enteral feeding tube the day after surgery.
Article Synopsis
- The study aimed to identify genetic mutations in the MEN1 gene among patients with a seemingly sporadic form of multiple endocrine neoplasia type 1 (MEN1).
- Genetic screening was conducted on 12 patients, revealing that 3 had pathogenic mutations, including a novel 18 base-pair deletion that affects protein structure.
- The findings highlight the necessity of genetic testing in sporadic MEN1 cases, suggesting that some may have underlying hereditary factors.