Publications by authors named "Daeyun Seo"

Objective: Liver compression (LC) has been proposed to predict fluid responsiveness in human pediatric patients. Because the evaluation of fluid responsiveness through LC depends on the mechanism of increased intra-abdominal pressure (IAP), understanding the impact of LC on IAP, cardiac output (CO), and respiratory parameters is essential. Thus, this study aimed to investigate the effects of LC on these parameters.

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Article Synopsis
  • Sarcopenia is the age-related loss of muscle mass and function, significantly impacting health as the population ages.
  • Mitochondrial dysfunction, particularly through mitochondrial reactive oxygen species (mtROS), plays a critical role in sarcopenia, and resistance exercise training (RET) may be beneficial despite traditional views favoring aerobic exercise for improving mitochondria.
  • This review explores how RET can positively influence mtROS, enhance mitochondrial biogenesis, improve mitochondrial dynamics, and promote mitophagy in aging muscles, offering strategies to combat sarcopenia and maintain muscle health.
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Objective: To investigate whether liver compression (LC) could increase stroke volume (SV) by more than 15% in healthy, anesthetized dogs with hypovolemia and suggest LC as a novel method to evaluate fluid responsiveness.

Animals: 6 healthy Beagles.

Methods: This prospective, nonrandomized experimental study was conducted from November 2023 to February 2024.

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  • * Diagnostic tests revealed increased pressure in the left eye and prolonged coagulation panels, indicating severe anemia and the presence of blood in the eye socket from retrobulbar fluid.
  • * The kitten received treatments including surgery to relieve pressure, blood transfusions, and medications, resulting in improved health over 14 days, although it suffered from permanent optic nerve damage and blindness.
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Objective: To measure the tracheal diameter and length in kittens using radiography and CT and to evaluate the concordance between measurements obtained with these 2 modalities.

Animals: 15 kittens with an estimated age of 12 weeks and mean body weight of 1.49 kg.

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Surgical procedures on large skin defects can be challenging in the short term due to the size of the lesion, infection, and tissue defect. A regenerative therapy for skin wounds has been applied to promote the healing process. An 8-month-old, Korean domestic short-haired female cat, weighing 3 kg, was rescued with extensive defects on the right flank to right inguinal region caused by bite wounds.

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Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases. The mitochondria receive signals regarding the metabolic states in cells and transmit them to the nucleus or endoplasmic reticulum (ER) using calcium (Ca2+) for appropriate responses. Overflux of Ca2+ in the mitochondria or dysregulation of the signaling to the nucleus and ER could increase the incidence of metabolic diseases including insulin resistance and type 2 diabetes mellitus.

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Although facial wounds caused by traffic accidents in dogs are common, the surgical management of severe facial injuries involving the soft tissue, bone, dentition, nose and orbit are challenging. A 2 year-old Korean Jindo dog was diagnosed with severe skin defects of the face and proptosis caused by a vehicular accident. Along the left lateral maxilla, severe injury involving the overlying skin and platysma muscle occurred, to the extent that the middle part of the sphincter colli profundus pars intermedia muscle was exposed.

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Aging is associated with vulnerability to cardiovascular diseases, and mitochondrial dysfunction plays a critical role in cardiovascular disease pathogenesis. Exercise training is associated with benefits against chronic cardiac diseases. The purpose of this study was to determine the effects of aging and treadmill exercise training on mitochondrial function and apoptosis in the rat heart.

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Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), pro-inflammatory cytokines, and reactive oxygen species. Exercise, which plays an important role in maintaining and improving brain health, might be a highly effective intervention for preventing neuroinflammation-related diseases.

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This study aimed to determine the effects of a single bout exercise on mitochondria-mediated apoptotic signaling in cardiac and skeletal muscles. Fischer 344 rats (4 months old) were randomly divided into the control or a single bout of exercise group (n=10 each). The rats performed a single bout of treadmill exercise for 60 min.

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Article Synopsis
  • - This study examined how a single session of exercise impacts mitochondrial function, dynamics, and mitophagy in the heart and skeletal muscles of Fischer 344 rats.
  • - The rats that exercised showed improved mitochondrial oxygen respiration and calcium retention, but mitochondrial fusion and fission were unchanged, with varied effects on mitophagy across different muscle types.
  • - The findings suggest that aerobic exercise enhances certain aspects of mitochondrial function without affecting the overall dynamics or the process of cleaning up damaged mitochondria.
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  • * This study examined how aging affects mitochondrial function in the hearts of different age groups of male Fischer 344 rats.
  • * Results showed that aging reduces essential mitochondrial proteins and increases reactive oxygen species production, while decreasing calcium retention capacity, indicating that mitochondrial dysfunction is a key factor in age-related heart issues.
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  • Obesity leads to changes in skeletal muscle and increased apoptosis (cell death) associated with mitochondria, which can negatively affect muscle function.
  • A study used four groups of mice to examine how exercise influences muscle structure and cell death in the context of obesity induced by a high-fat diet.
  • The findings indicate that exercise helps improve muscle structure and reduces apoptosis in obese mice, highlighting its potential protective effects on skeletal muscle health.
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