Apoptotic cell death of stomach cancer lines (AGS) induced by Co-NTB complex through cellular organelles and DNA damage.

Given that stomach cancer is the fourth leading cause of cancer-related death, there is a need to develop new drugs. Among various methods, metal-based coordination compounds are considered as an efficient strategy against this type of cancer. Similarly, the benzimidazole moiety plays a crucial role in biology; thus, various benzimidazole-based compounds have been found to be active as potential anticancer drugs and are currently used in clinical trials.

Structural isomers of carene persuade apoptotic cell death by inhibiting cell cycle in breast cancer cells: An in silico and in vitro approach.

For the first time, our study provides a comprehensive examination of the anti-cancer effects of structural isomers of carene in breast cancer cells, specifically focusing on cell cycle inhibition and the induction of apoptosis. We utilized the hydro-distillation method to extract Piper nigrum seed essential oil (PNS-EO) and identified its bioactive components through gas chromatography-mass spectrometry (GC-MS) analysis. A total of 46 bioactive compounds were isolated via hydro-distillation, identified through GC-MS analysis, and validated by co-injection using GC analysis.

Nanocarbon eco-hydrogel kit: on-site visual metal ion sensing and dye cleanup, advancing the circular economy in environmental remediation.

The naked-eye detection of hazardous pollutants through simple and cost-effective techniques is of great interest to the scientific community and related stakeholders in analytical science. The present study emphases the development of a stimuli-responsive probe by encountering sophisticated techniques for the detection of environmental pollutants. Herein, highly swellable and fluorescent-WTR-CDs-loaded HB-Alg/Gel@WTR-CDs was fabricated through a simple extrusion dripping method.

Facile synthesis of sulphur-doped carbon dots (S-CDs) using a hydrothermal method for the selective sensing of Cr and Fe ions: application to environmental water sample analysis.

In this work, we used a one-step hydrothermal method to synthesize blue-emission sulfur-doped carbon dots (S-CDs) using jaggery as a carbon precursor. The synthesized carbon quantum dots showed low toxicity, good water solubility, anti-interference properties, and stable fluorescence. When excited at 310 nm, the S-CDs produced bright emission with a quantum yield of 7.

Route-dependent tailoring of carbon dot release in alginate hydrogel beads (HB-Alg@WTR-CDs): A versatile platform for biomedical applications.

The present investigation explores the different pathways for development of waste tea residue carbon dots (WTR-CDs) loading into hydrogel matrix for WTR-CDs releasing probe. Fluorescent WTR-CDs incorporated into hydrogel matrix were synthesized by valorisation of kitchen waste tea by simple carbonization method (λ = 450 nm, Φ =18.45 %).

Green, facial zinc doped hydrothermal synthesis of cinnamon derived fluorescent carbon dots (Zn-Cn-CDs) for highly selective and sensitive Cr and Mn metal ion sensing application.

Carbon dots have demonstrated a great potential as luminescent nanoparticles in energy, drug delivery, sensors, and various biomedical applications as well as environmental pollutants and water analysis. Although, such nanoparticles appear to exhibit low toxicity compared to other semiconductor and metal based luminescent nanomaterials. Today, we know that toxicity of carbon dots (CDs) strongly depends on the protocol of fabrication.

Cardiac sarcoidosis.

The diagnostic yield of endomyocardial biopsy in cardiac sarcoidosis (CS) is quite low because of the patchy involvement, and for the diagnosis of CS, existing guidelines required histological confirmation. Therefore, especially for isolated CS, diagnosis consistent with the guidelines cannot be made in a large number of patients. With recent developments in imaging modalities such as cardiac magnetic resonance and 18-fluorodeoxyglucose positron emission tomography, diagnosing CS has become easier and diagnostic criteria for CS not compulsorily requiring histological confirmation have been suggested.

Mapping Out the Nonconjugated Organic Radical Conductors via Chemical or Physical Pathways.

Stable, nitroxide-based organic radicals have gained tremendous attention in a wide range of research fields, ranging from solid-state electronics to energy storage devices. While the success of these organics has been their designer flexibility and the processability that can fully potentiate the open-shell chemistry, a significant knowledge gap exists on the solid-state electronics of small-molecular radicals. Herein, we examine the structure-property relationship that governs the solid-state electronics of a model nitroxide and its derivatives by seeking the connection to their well-established, electrolyte-based chemistry.

Network Analysis of Cardiac Remodeling by Primary Mitral Regurgitation Emphasizes the Role of Diastolic Function.

Background: Topological data analysis (TDA) can generate patient-patient similarity networks by analyzing large, complex data and derive new insights that may not be possible with standard statistics.

Objectives: The purpose of this paper was to discover novel phenotypes of chronic primary mitral regurgitation (MR) patients and to analyze their clinical implications using network analysis of echocardiographic data.

Methods: Patients with chronic moderate to severe primary MR were prospectively enrolled from 11 Asian tertiary hospitals (n = 850; mean age 56.

Triiodide-in-Iodine Networks Stabilized by Quaternary Ammonium Cations as Accelerants for Electrode Kinetics of Iodide Oxidation in Aqueous Media.

The Zn-polyiodide redox flow battery is considered to be a promising aqueous energy storage system. However, in its charging process, the electrode kinetics of I oxidation often suffer from an intrinsically generated iodine film (I-F) on the cathode of the battery. Therefore, it is critical to both understand and enhance the observed slow electrode kinetics of I oxidation by an electrochemically generated I-F.

Independent Prognostic Utility of C-Pittsburgh Compound B PET in Patients with Light-Chain Cardiac Amyloidosis.

C-Pittsburgh compound B (PiB) PET/CT visualizes the amount of myocardial amyloid deposit and can be used to prognosticate patients with amyloid light-chain (AL) cardiac amyloidosis (CA). However, whether C-PiB PET/CT has any independent additional prognostic value beyond the commonly used biomarkers remains unknown. This prospective study was on a cohort of 58 consecutive patients with AL CA who underwent C-PiB PET/CT.

Reduced acoustic resonator dimensions improve focusing efficiency of bacteria and submicron particles.

In this study, we demonstrate an acoustofluidic device that enables single-file focusing of submicron particles and bacteria using a two-dimensional (2D) acoustic standing wave. The device consists of a 100 μm × 100 μm square channel that supports 2D particle focusing in the channel center at an actuation frequency of 7.39 MHz.

Sawmill waste derived carbon dots as a fluorescent probe for synthetic dyes in soft drinks.

Herein, for the first time the carbon dots (CDs) were synthesized by reflux method from sawmill waste material. We also represent a novel strategy based on fluorescent CDs for determination of ponceau 4R and allura red dyes in soft drinks. Interestingly, both the dyes were sensitive and showed effective fluorescence quenching of the CDs owing to the interaction between them.

Prognostic implications of left ventricular mass-geometry in patients with no or nonobstructive coronary artery disease.

Background: Coronary computed tomography angiography (CCTA) is widely used as a first-line noninvasive modality that frequently exhibits no or nonobstructive coronary artery disease (CAD) in clinical practice, along with abnormal left ventricular (LV) geometry on echocardiography. However, the combined prognostic value of these findings has not been well elucidated. Therefore, we aimed to evaluate the prognostic implications of abnormal LV geometry in individuals with no or nonobstructive CAD.

Carbon Nanodots Derived from Kitchen Waste Biomass as a Growth Accelerator for Fenugreek Plant.

Herein, we report the utilization of kitchen waste biomass as a source of carbonaceous material for carbon nanodots synthesis and its application as a plant growth regulator in agricultural crops. The water soluble carbon dots (CDs) were synthesized by pyrolysis of kitchen derived waste tea residue (WTR) and used in the field of agriculture nanotechnology. Herein, we have explored the effect of different concentrations of WTR-CDs (10, 30 and 50 mg/L) on growth of FG with respect to various plant growth parameters.

Discrepancy of Aortic Valve Area Measurements by Doppler vs. Biplane Stroke Volume Measurements and Utility of Combining the Different Areas in Aortic Valve Stenosis - The Asian Valve Registry.

Background: The aortic valve area index (AVAI) in aortic stenosis (AS) is measured by echocardiography with a continuity equation using the stroke volume index by Doppler (SVI) or biplane Simpson (SVI) method. AVAIand AVAIoften show discrepancy due to differences between SVIand SVI. The degree of discrepancy and utility of combined AVAIs have not been investigated in a large population of AS patients, and the characteristics of subjects with larger discrepancies are unknown.

Diffuse Myocardial Fibrosis and Diastolic Function in Aortic Stenosis.

Objectives: The aim of this study was to investigate the relationship between extracellular volume fraction (ECV), a noninvasive parameter that quantifies the degree of diffuse myocardial fibrosis on cardiac magnetic resonance (CMR), and left ventricular diastolic dysfunction (LVDD) in patients with aortic stenosis (AS).

Background: Myocardial fibrosis on invasive myocardial biopsy is associated with LVDD. However, there is a paucity of data on the association between noninvasively quantified diffuse myocardial fibrosis and the degree of LVDD and how these are related to symptoms and long-term prognosis in patients with AS.

Time trajectory of cardiac function and its relation with survival in patients with light-chain cardiac amyloidosis.

Aims: We aimed to analyse the time-serial change of cardiac function in light-chain (AL) cardiac amyloidosis patients undergoing active chemotherapy and its relationship with patient outcome.

Methods And Results: Seventy-two patients with AL cardiac amyloidosis undergoing active chemotherapy who had two or more echocardiographic examinations were identified from a prospective observational cohort (n = 34) and a retrospective cohort (n = 38). Echocardiographic parameters were obtained immediately prior to 1-3, 3-6, 6-12, and 12-24 months after the first chemotherapy.

Making Nonconjugated Small-Molecule Organic Radicals Conduct.

Charge neutral, nonconjugated organic radicals have emerged as extremely useful active materials for solid-state electronic applications. This previous achievement confirmed the potential of radical-based macromolecules in organic electronic devices; however, charge transport in radical molecules has not been studied in great detail from a fundamental perspective. Here we demonstrate the charge transport in a nonconjugated organic small radical, 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (h-TEMPO).

Different effects of SGLT2 inhibitors according to the presence and types of heart failure in type 2 diabetic patients.

Background: The effects of sodium-glucose cotransporter 2 inhibitor (SGLT2i) on cardiac function are not fully understood. We investigated the changes in cardiac function in diabetic patients according to the presence and types of heart failure (HF).

Methods: We retrospectively identified 202 diabetic patients who underwent echocardiography before, and 6 to 24 months after the initiation of SGLT2i.

Unsupervised Cluster Analysis of Patients With Aortic Stenosis Reveals Distinct Population With Different Phenotypes and Outcomes.

Background: There is a lack of studies investigating the heterogeneity of patients with aortic stenosis (AS). We explored whether cluster analysis identifies distinct subgroups with different prognostic significances in AS.

Methods: Newly diagnosed patients with moderate or severe AS were prospectively enrolled between 2013 and 2016 (n=398, mean 71 years, 55% male).

Myocardial structural and functional changes in patients with liver cirrhosis awaiting liver transplantation: a comprehensive cardiovascular magnetic resonance and echocardiographic study.

Background: Cardiac dysfunction is increasingly recognized in patients with liver cirrhosis. Nevertheless, the presence or absence of structural alterations such as diffuse myocardial fibrosis remains unclear. We aimed to investigate myocardial structural changes in cirrhosis, and explore left ventricular (LV) structural and functional changes induced by liver transplantation.

Dataset on the shooting and rooting ability of using waste tea residue derived carbon dots as an alternative of growth plant stimulator.

The data article (vegetative plant propagation) culture techniques are sustainable alternatives to the large-scale production of economically important plant species. is an essential species that is mainly considered to be economically important due to their potential use as silk production, medicine and food. In this work, we evaluated the data of effects of different concentration of Waste Tea Residue Carbon Dots (WTR-CDs) on the ex vitro growth of morus.