Publications by authors named "Dae-Wook Yang"
Article Synopsis
- Regulation of cell survival is vital for organ development, with TCTP playing a key role in both normal growth and tumor formation.
- The study found that inhibiting Topoisomerase II (TOP2) in Drosophila wing and eye discs led to tissue loss and increased cell death, highlighting TOP2's importance for cell survival.
- TCTP and TOP2 levels are mutually regulated; decreasing one affects the other, and maintaining proper levels of TOP2 is crucial for healthy organ development.
Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
Cell Death Differ
January 2021
Article Synopsis
- The study examines the roles of Patronin and Klp10A in Drosophila, focusing on their impact on cell survival and organ size during development, highlighting the importance of the microtubule network.
- Loss of Patronin leads to decreased organ size due to activated cell death pathways, which can be mitigated by knocking down other proteins like Spastin or overexpressing anti-apoptotic factors.
- The findings suggest that Patronin and Klp10A have opposing effects on microtubule regulation and are crucial for maintaining appropriate organ size and survival by influencing Hippo pathway components.
The inhibitory effect of large tumor suppressor kinase (LATS1/2) on the activity of the oncoprotein yes-associated protein (YAP) is crucial to maintain tissue homeostasis. Proteomic studies have identified several new regulators of this process. Recently, citron kinase (CIT) was listed as a potential binding candidate of Hippo-related components, suggesting a new connection between CIT and the Hippo pathway.
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