The stimulation protocol in poor responder IVF; a minimal or high-dose stimulation? - A meta-analysis.

Background To determine whether a minimal stimulation (MS) or high-dose stimulation (HDS) protocol is a better option for patients classified as poor ovarian responders (POR) in terms of reproductive and pregnancy outcomes. Materials and methods A database search for evaluation of the study outcome by using meta-analysis method was carried out. The primary outcome was the clinical pregnancy (CP) rate for each of two groups, namely, the MS and HDS groups.

Quantification of antigen by digital domain analysis of integrated nanogap biosensors.

Nanogap biosensor shows a distinct conduction change upon sandwich-type immobilization of gold nanoparticle probes onto the gap region in the presence of target biomolecules. Although this large conductance change could be advantageous in distinguishing signal on or off devices, since the extent of conductance change is quite irregular even at the same analyte concentrations, it fails to extract quantitative information from its level of conductance change. In other words, the conductance change of a single device does not reflect the concentration of the target molecule.

Gradient-Field-Plasma Modification of Imprinted Nanopatterns.

We report on a one-step progressive modification of imprinted nanopatterns for the induction of a structural and physicochemical gradient in a single chip with the use of gradually attenuated oxygen plasma. Imprinted line patterns could be easily tapered off to up to 60% of their original line width, which was found to be dependent upon the rate of plasma attenuation. Gradually modified nanopatterns are believed to have a continuous variation of physicochemical properties along the pattern gradient, which in this study was exemplified in contact angle variation, which was observed to be more than a factor of about 5 in 2 cm separation on a sample surface.

Fabrication of shape-controlled reduced graphene oxide nanorings by Au@Pt nanoring lithography.

We fabricated a variety of reduced graphene oxide (RGO) nanoring arrays using Au@Pt nanoplates as a pattern mask. RGO nanoflakes were assembled into a 2-dimensional assembly at the water-oil interface, and then various shapes of Au@Pt nanoplates were utilized as a pattern mask in order to convert the RGO into circular, triangular, and hexagonal RGO nanorings.

Nanogap-based electrical PNA chips for the detection of genetic polymorphism of cytochrome P450 2C19.

PNA chips for the detection of the genetic polymorphism of Cytochrome P450 2C19 (CYP2C19), a well-known enzyme related to the metabolism of therapeutic drugs, were electrically-interfaced with interdigitated nanogap electrodes (INEs). The average gap distance and effective length of the INEs were about approximately 70 nm and approximately 140/m, respectively. Those INEs having the aspect ratio of about 2000, were prepared by the combination of the photolithography (for the formation of initial electrodes) and the surface-catalyzed chemical deposition (for the gap narrowing), without the e-beam lithography.