Transforming HIV prevention: the promise of long-acting preexposure prophylaxis in high HIV burden settings.

Purpose Of Review: Recent research on efficacy and safety of long-acting preexposure prophylaxis (PrEP) holds the promise to transform HIV prevention in high HIV burden settings. We review emerging findings regarding early end-user acceptability of long-acting PrEP modalities, feasibility of integrating long-acting PrEP into health systems, and considerations regarding drug resistance and cost.

Recent Findings: Long-acting PrEP, particularly injectables, was found to be highly acceptable among individuals across key populations in high HIV burden settings.

Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study.

Background: There are few data on tenofovir-diphosphate (TFV-DP) concentrations in pregnant and postpartum women on Tenofovir Disoproxil Fumarate-Emtricitabine (TDF-FTC) or Tenofovir Alafenamide-Emtricitabine (TAF-FTC).

Methods: Eligible pregnant women were randomized to TDF-FTC or TAF-FTC and followed for 16 weeks (8-weeks pregnant, 8-weeks postpartum) with weekly collection of dried blood spot (DBS) and 4-weekly peripheral blood mononuclear cells (PBMC). PrEP dosing was observed daily via asynchronous videos sent via cell phone.

Unchecked Antibiotic Access: A Looming Crisis in Pakistan.

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Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers.

Introduction And Objective: Eosinophilic esophagitis is a chronic, immune-mediated disease described in case series and publications worldwide. Over the past twenty years, the authors of different studies have attempted to evaluate its incidence and prevalence. The objetive of the present study was to estimate the prevalence of eosinophilic esophagitis in a group of children seen at 36 pediatric gastroenterology centers in ten Latin American countries.

[Profile of gastrointestinal diseases in a pediatric gastroenterology center in Colombia: 15 years of follow-up].

Introduction: The profile of gastrointestinal diseases is constantly changing globally and locally affecting suspected diagnosis and medical methods.

Objective: To establish the main diagnoses in a gastroenterology, hepatology, and pediatric nutrition unit in Bogota between 2009 and 2013, and to compare with findings from the same unit during the two prior five-year periods (1997 to 2006).

Materials And Methods: We conducted a retrospective descriptive study.

[Pediatric gastrointestinal disorders at hight altitude. Report of two cases and review of literature.].

Upon ascending above 2500 meters sea level, the human body undergoes a series of physiological changes that have been studied during years. These changes undertake various systems including gastrointestinal tract, with diverse clinical manifestations, most mild and therefore little reported and are underdiagnosed. Two pediatric patients who atended to the Pediatric Unit of Gastroenterolog, Hepatolog and Nutrition (Gastronutriped) in Bogota, in whose we documented symptoms affecting gastrointestinal tract associated with high altitude.

[Cardiovascular risk factors in healthy adult men: influence of physical activity and dietary habits].

Objective: To study the influence of physical activity and certain dietary habits on cardiovascular risk factors in middle age men.

Design: Prospective cross sectional study.

Setting: Primary care.