Publications by authors named "Dachao Liang"

Objective: Approximately 7% of individuals with dystrophinopathy remain undiagnosed at the genetic level using conventional genetic tests like multiplex ligation-dependent probe amplification (MLPA) and next-generation sequencing (NGS). We used the optical genome mapping (OGM) technology to detect and analyze uncommon mutations or structural variations (SVs) within the DMD gene, thus contributing to more precise clinical diagnoses.

Methods: We herein included eight patients with dystrophinopathy (six males and two females) in whom pathogenic variants of the DMD gene could not be accurately identified using MLPA and NGS.

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Background: Tuberous sclerosis is a multi-system disorder caused by mutations in either or . The majority of affected patients (85%-90%) have heterozygous variants, and a smaller number (around 5%) have mosaic variants. Despite using various techniques, some patients still have "no mutation identified" (NMI).

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Background: Despite substantial resources deployed to curb SARS-CoV-2 transmission, controlling the COVID-19 pandemic has been a major challenge. New variants of the virus are frequently emerging leading to new waves of infection and re-introduction of control measures. In this study, we assessed the effectiveness of containment strategies implemented in the early phase of the pandemic.

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Article Synopsis
  • The human microbiome, consisting of various microorganisms in our body, impacts energy metabolism and immunity, playing a significant role in the development of numerous diseases.
  • Despite extensive research in the last decade, there are still many unresolved questions about how the microbiome affects human health, and no widely accepted conclusions have been reached.
  • This review aims to summarize current findings, highlight knowledge gaps, and suggest research opportunities, focusing on topics like animal physiology, microbiome manipulation for health interventions, and the implications of microbiota structure on human diseases.
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Article Synopsis
  • * By analyzing over 250 gene sequences collected from 27 countries between 1947 and 2016, researchers traced the virus's transmission in various regions and suggested that its origin in Eastern Africa might not be as clear-cut as previously thought.
  • * The study identified significant amino acid changes and hypothesized historical events in the 1940s that may have contributed to ZIKV's spread from Africa to South-eastern Asia, emphasizing the need for further genetic research to shape prevention strategies.
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