Comparison between the effect of glibenclamide and captopril on experimentally induced diabetic nephropathy in rats.

Hypothesis: This study aimed to elucidate the role of glibenclamide in the prevention of diabetic nephropathy and to compare it with a reference drug captopril in rats.

Materials And Methods: There were two main groups of rats. Control group (I) was subdivided into four subgroups which received distilled water, vehicle of streptozotocin, glibenclamide or captopril.

Autoimmune thrombocytopenia. Is it a different disease or different aspects of a single disease?

Objective: To evaluate the association between autoimmune thrombocytopenia with other autoimmune disorders, to show if they are different autoimmune diseases or one disease with different presentations at the same time, and to study the effect of treatment on platelet count in different thyroid condition.

Methods: In this retrospective study, we included 141 patients with thrombocytopenic purpura. The result of thyroid function test, thyroid autoantibodies, Coombs' reactivity, anti-nuclear antibody, and double-stranded DNA were analyzed.

Estimation of insulin resistance in non-diabetic normotensive Saudi adults by QUICKI, HOMA-IR and modified QUICKI: a comparative study.

Background And Objectives: Identification of insulin resistance (IR) in the general population is important for developing strategies to reduce the prevalence of non-insulin-dependent diabetes mellitus (NIDDM). We used the original and a modified version of the Quantitative Insulin Sensitivity Check Index (QUICKI, M-QUICKI), and the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to divide non-diabetic normotensive adults into high- (HIR) and low-insulin-resistant (LIR) subgroups to investigate similarities and differences in their characteristics.

Subjects And Methods: Three hundred fifty-seven healthy adults aged 18-50 years were recruited randomly from health centers in Jeddah in a cross-sectional study design.

Helicobacter pylori infection at a university hospital in Saudi Arabia: prevalence, comparison of diagnostic modalities and endoscopic findings.

The presence of Helicobacter pylori (H. pylori) was examined in 491 sequential patients, complaining mainly of epigastric pain, by three biopsy-based methods (rapid urease, histology, and culture), and by a serological test, enzyme immunosorbent assay, (ELISA). H.

Non-alcoholic fatty liver disease and metabolic syndrome: what we know and what we don't know.

NAFLD is a very common asymptomatic liver condition that may progress to cirrhosis and hepatocellular carcinoma, and a relation to the different components of the metabolic syndrome has been found. In this review we highlight some of the epidemiological aspects of the two disorders and discuss some of the possible mechanisms and questions to be answered concerning the risk factors for the progression of this condition, as well as the need for more studies to focus on possible modalities of treatment.

Subclinical hypothyroidism in elderly women attending an outpatient clinic.

Background: The object was to determine the frequency of subclinical hypothyroidism (SH) in elderly women and study its relation to serum lipids, hypertension, diabetes, and ischemic heart disease.

Material/methods: A sample of 257 patients was randomly selected among women above the age of 50 visiting the King Abdulaziz University outpatient clinic. All were examined for thyroid function.

A case of rifampicin induced pseudomembraneous colitis.

We report a case pf pseudomembranous colitis that developed in a patient with tuberculous abdominal lymphadenopathy during treatment with rifampicin. The patient had delayed presentation (3 months) after the start of rifampicin. She had one relapse after 2 months that was successfully treated, and she finished her antituberculosis therapy without any further relapses.

Sub-optimal postprandial blood glucose level in diabetics attending the outpatient clinic of a University Hospital.

Objective: To determine the frequency of diabetic patients who attained the optimal postprandial blood glucose level.

Methods: Cross-sectional study of type-2 diabetic patients being followed at the medical outpatient clinic of King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia, from January 1999 to December 2001. Patients were classified according to postprandial blood glucose level into 3-categories; group-1 (<9 mmol/l), group-2 (9.

Poor lipid control in type-2 diabetics with and without ischemic heart disease.

To determine the frequency of type-2 diabetics who have target lipoprotein blood levels, to study these levels in patients with ischemic heart disease and cardiovascular disease risk factors, and to study the possible causes of poor control, we reviewed hyperlipdemic type-2 diabetics who were on regular follow up to the medical outpatient clinic of King Abdulaziz University Hospital from January 2000 to January 2001. A total of 202 patients were studied with mean age of 60 yr and equal male to female ratio. The mean duration of diabetes was 10 yr and it was 7 yr for hyperlipidemia.

Is hypertension well controlled in hypertensive diabetics.

Objective: To determine the degree of blood pressure (BP) control in hypertensive diabetics and to study the types of antihypertensive agents used for BP control.

Methods: A cross-sectional study was carried out on hypertensive diabetics followed in the outpatient clinic of King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia from January 2000 to February 2001. Patient's age, sex, duration of diabetes and its control, duration of hypertension and the type of antihypertensive agents used, were noted.

Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome.

The objective of this study was to examine the effect of the antihyperglycemic agents metformin (insulin sensitizer) and glibenclamide (insulin secretory agent) on the serum level of C-reactive protein (CRP) in well-controlled type 2 diabetics with metabolic syndrome. The participants were diabetic patients being followed in the medical outpatient clinic of King Abdulaziz University Hospital. The inclusion criteria were type 2 diabetics with the metabolic syndrome, well-controlled blood glucose on metformin alone or glibenclamide alone, and exclusion of major medical illness.

The insulin resistance syndrome among type II diabetics.

Objective: The aim of this study is to determine the prevalence of insulin resistance syndrome among type-II Saudi diabetics.

Methods: The study involved type-II Saudi diabetics followed at the Out-patient Clinic of King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia, from January 1997 to December 1998. Their age, sex and body mass index was recorded.

Prevalence of Type-2 diabetes in patients with hepatitis C and B virus infection in Jeddah, Saudi Arabia.

Objectives: To determine the prevalence of type-2 diabetes mellitus (DM) in patients with hepatitis C virus (HCV) and B virus (HBV) infections.

Materials And Methods: A cross-sectional study of HCV- and HBV-positive patients admitted to King Abdul Aziz University Hospital, Jeddah, Saudi Arabia, was conducted from January 1999 to September 2000. The following data were collected and analysed: demographic data, the presence and type of DM, details of the treatment, body mass index (BMI), family history of DM, serum transaminases, thrombocytopenia, and presence of liver cirrhosis on liver biopsy.

Low aspirin use in diabetics.

Objective: To determine the percentage of adult diabetics with cardiovascular disease, or risk factors for cardiovascular disease who are using aspirin, and to report on any differences between males and females, or Saudis and non-Saudis.

Methods: Medical records of diabetics seen at King Abdulaziz University Hospital during the period January 1998 through to December 2000 were analyzed. The following data were collected: patients age, sex, nationality, body mass index, duration of diabetes, history of cardiovascular disease, risk factors for cardiovascular disease (hypertension, hyperlipidemia, obesity, smoking, family history of ischemic heart disease) and aspirin use.

Clinical profile of stroke:: The experience at King Abdulaziz University Hospital.

Objectives: To determine the pattern and risk factors of stroke in Saudi nationals and non-Saudis, at King Abdulaziz University Hospital (KAUH), in the western province of Saudi Arabia.

Method: All cases of stroke admitted to KAUH in the period between January 1995 and December 1999 were studied. Demographic data of the patients, stroke types, risk factors and mortality were reported.